5'-POSITION DIBENZYL PHOSPHORIC ACID ESTER OF 5-AZACYTIDINE OR 2'-DEOXY BODY THEREOF

Title:

5'-POSITION DIBENZYL PHOSPHORIC ACID ESTER OF 5-AZACYTIDINE OR 2'-DEOXY BODY THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/090264

Kind Code:

A1

Abstract:

[Problem] To provide a drug that substitutes for injections (5-azacytidine or 2'-deoxy-5-azacytidine) that are clinically used as bone marrow tumor therapeutic drugs, said drug having high stability with respect to metabolic enzyme cytidine deaminase, being absorbed in the body even by means of oral administration, and having an effect of being integrated into an RNA and DNA biosynthesis pathway and inhibiting protein synthesis. [Solution] The abovementioned problem is solved by a novel compound represented by formula (1): (in the formula, R is a hydroxyl group or a hydrogen atom, and R1 and R2 are benzyl groups that may have a substituent group).

More Like This:

WO/2013/040257	5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING
WO/2019/236777	METHODS OF MONITORING, TREATING, AND PREVENTING RENAL INFLAMMATION ASSOCIATED WITH NEPHROTOXICITY
JPH09506333	[Title of Invention] Dosing method of therapeutic compound

Inventors:

SAKO MAGOICHI (JP)
LUO XIONG (JP)

Application Number:

PCT/JP2016/065659

Publication Date:

June 01, 2017

Filing Date:

May 27, 2016

Export Citation:

Click for automatic bibliography generation Help

Assignee:

OHARA PHARMACEUTICAL CO LTD (JP)

International Classes:

C07H19/10; A61K31/7068; A61P31/04; A61P35/00; A61P43/00

Domestic Patent References:

WO2011153374A1	2011-12-08
WO2012166645A1	2012-12-06
WO2011113173A1	2011-09-22

Other References:

KIMURA, JUNJI ET AL.: "Studies on Nucleosides and Nucleotides. VIII. Preparation and Reactions of Triphenylphosphoranediylnucleosides", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 53, no. 12, 1980, pages 3670 - 3677, XP055388536, DOI: doi:10.1246/bcsj.53.3670
PRAKASH, THAZHA P. ET AL.: "Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5'-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 4, 2005, pages 1199 - 1210, XP055139909, DOI: doi:10.1021/jm0495172

Attorney, Agent or Firm:

SHA Takuho (JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: COMPRESSOR MODULE, AIR CONDITIONING DEVICE FOR VEHICLE AND COMPRESSOR MODULE MANUFACTURING METHOD

Next Patent: ANGLE DETECTION DEVICE AND ELECTRIC POWER STEERING DEVICE