Title:
55158, A NOVEL HUMAN CARBONIC ANHYDRASE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2001090321
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acid molecules, designated CAH nucleic acid molecules, which encode novel CAH-related carbonic anhydrase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CAH nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CAH gene has been introduced or disrupted. The invention still further provides isolated CAH proteins, fusion proteins, antigenic peptides and anti-CAH antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Inventors:
KAPELLER-LIBERMANN ROSANA (US)
Application Number:
PCT/US2001/016270
Publication Date:
May 10, 2002
Filing Date:
May 18, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
KAPELLER LIBERMANN ROSANA (US)
KAPELLER LIBERMANN ROSANA (US)
International Classes:
C12N9/88; (IPC1-7): C12N9/88; C12Q1/68; G01N33/53
Domestic Patent References:
| WO2001064834A2 | 2001-09-07 |
Foreign References:
| US5972684A | 1999-10-26 |
Other References:
KLEIDERLEIN JOHN J ET AL: "CCG repeats in cDNAs from human brain.", HUMAN GENETICS, vol. 103, no. 6, December 1998 (1998-12-01), pages 666 - 673, XP000907453, ISSN: 0340-6717
BELLINGHAM JAMES ET AL: "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 253, no. 2, 18 December 1998 (1998-12-18), pages 364 - 367, XP002191045, ISSN: 0006-291X
LOVEJOY DAVID A ET AL: "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: The human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3.", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 484 - 493, XP001056419, ISSN: 0888-7543
FUJIKAWA-ADACHI K ET AL: "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1431, no. 2, 18 May 1999 (1999-05-18), pages 518 - 524, XP004278704, ISSN: 0167-4838
HEWETT-EMMETT DAVID ET AL: "Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families.", MOLECULAR PHYLOGENETICS AND EVOLUTION, vol. 5, no. 1, 1996, pages 50 - 77, XP001056423, ISSN: 1055-7903
SLY W S ET AL: "HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 64, 1995, pages 375 - 401, XP000943172, ISSN: 0066-4154
OKAMOTO N ET AL: "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1518, no. 3, 16 April 2001 (2001-04-16), pages 311 - 316, XP004235052, ISSN: 0167-4781
BELLINGHAM JAMES ET AL: "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 253, no. 2, 18 December 1998 (1998-12-18), pages 364 - 367, XP002191045, ISSN: 0006-291X
LOVEJOY DAVID A ET AL: "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: The human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3.", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 484 - 493, XP001056419, ISSN: 0888-7543
FUJIKAWA-ADACHI K ET AL: "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1431, no. 2, 18 May 1999 (1999-05-18), pages 518 - 524, XP004278704, ISSN: 0167-4838
HEWETT-EMMETT DAVID ET AL: "Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families.", MOLECULAR PHYLOGENETICS AND EVOLUTION, vol. 5, no. 1, 1996, pages 50 - 77, XP001056423, ISSN: 1055-7903
SLY W S ET AL: "HUMAN CARBONIC ANHYDRASES AND CARBONIC ANHYDRASE DEFICIENCIES", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 64, 1995, pages 375 - 401, XP000943172, ISSN: 0066-4154
OKAMOTO N ET AL: "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1518, no. 3, 16 April 2001 (2001-04-16), pages 311 - 316, XP004235052, ISSN: 0167-4781
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