Title:
9-DEXO-9A-AZA-9A-METHYL-9A-HOMOERYTHROMYCIN A DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003077830
Kind Code:
A3
Abstract:
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a- homo erythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or 2, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group P21 and average unit cell parameters comprising: crystal axis lengths of a = 15.5 - 17.0 Å, b = 15.5 - 17.0 Å, and c = 17.5 - 19.5 A, and angles between the crystal axes of alpha. = gamma = 90° and beta = 106° - 112°. In addition, this disclosure is directed to processes for the preparation of the substantially pure isostructural pseudopolymorphs of Formula I; to pharmaceutical compositions containing substantially pure isostructural pseudopolymorphs of Formula I; and to a method for the treatment of bacterial and protozoan infections, and inflammation-related diseases by administration of a pharmaceutical composition containing the substantially pure isostructural pseudopolymorphs of Formula I.
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Application Number:
PCT/IB2003/000987
Publication Date:
May 13, 2004
Filing Date:
March 18, 2003
Export Citation:
Assignee:
PLIVA D D (HR)
International Classes:
A61K31/70; A61K31/7052; A61P29/00; A61P31/04; A61P33/02; C07H17/00; C07H17/08; A61K; C07H; (IPC1-7): C07H17/00; A61K31/70; A61P33/02; A61P31/04; C07H17/08
Domestic Patent References:
WO2003053399A2 | 2003-07-03 | |||
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WO1999058541A2 | 1999-11-18 | |||
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WO2001000640A1 | 2001-01-04 | |||
WO2000032203A1 | 2000-06-08 | |||
WO2001087912A1 | 2001-11-22 |
Foreign References:
EP1103558A2 | 2001-05-30 | |||
EP0984020A2 | 2000-03-08 | |||
EP0827965A2 | 1998-03-11 | |||
EP0298650A2 | 1989-01-11 | |||
US6268489B1 | 2001-07-31 |
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