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Title:
9-DEXO-9A-AZA-9A-METHYL-9A-HOMOERYTHROMYCIN A DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003077830
Kind Code:
A3
Abstract:
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a- homo erythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or 2, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group P21 and average unit cell parameters comprising: crystal axis lengths of a = 15.5 - 17.0 Å, b = 15.5 - 17.0 Å, and c = 17.5 - 19.5 A, and angles between the crystal axes of alpha. = gamma = 90° and beta = 106° - 112°. In addition, this disclosure is directed to processes for the preparation of the substantially pure isostructural pseudopolymorphs of Formula I; to pharmaceutical compositions containing substantially pure isostructural pseudopolymorphs of Formula I; and to a method for the treatment of bacterial and protozoan infections, and inflammation-related diseases by administration of a pharmaceutical composition containing the substantially pure isostructural pseudopolymorphs of Formula I.

Application Number:
PCT/IB2003/000987
Publication Date:
May 13, 2004
Filing Date:
March 18, 2003
Export Citation:
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Assignee:
PLIVA D D (HR)
International Classes:
A61K31/70; A61K31/7052; A61P29/00; A61P31/04; A61P33/02; C07H17/00; C07H17/08; A61K; C07H; (IPC1-7): C07H17/00; A61K31/70; A61P33/02; A61P31/04; C07H17/08
Domestic Patent References:
WO2003053399A22003-07-03
WO2002015842A22002-02-28
WO1999058541A21999-11-18
WO2002010144A12002-02-07
WO2001049697A12001-07-12
WO2001000640A12001-01-04
WO2000032203A12000-06-08
WO2001087912A12001-11-22
Foreign References:
EP1103558A22001-05-30
EP0984020A22000-03-08
EP0827965A21998-03-11
EP0298650A21989-01-11
US6268489B12001-07-31
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