Title:
ABCC11 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/033773
Kind Code:
A1
Abstract:
The present invention provides a 12-transmembrane multidrug resistance-associated protein inhibitor that comprises, as an active ingredient, a compound for treating hyperuricemia or a salt thereof. In one embodiment, the compound is represented by general formula I. In one embodiment, the 12-transmembrane multidrug resistance-associated protein is ABCC11. The inhibitor of the present invention is usable particularly in a medicinal composition or cosmetic composition for preventing or treating axillary osmidrosis.
Inventors:
TOYODA YU (JP)
TAKADA TAPPEI (JP)
SUZUKI HIROSHI (JP)
TAKADA TAPPEI (JP)
SUZUKI HIROSHI (JP)
Application Number:
PCT/JP2020/031672
Publication Date:
February 25, 2021
Filing Date:
August 21, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K8/49; A61K45/00; A61P17/00; A61P43/00; A61Q15/00
Domestic Patent References:
| WO2007148835A1 | 2007-12-27 | |||
| WO2018023126A1 | 2018-02-01 |
Foreign References:
| JP2725886B2 | 1998-03-11 | |||
| US201962890053P | 2019-08-21 |
Other References:
EL-SHEIKH, AAK, VAN DEN HEUVEL J J M W, KOENDERINK J B, RUSSEL F G M: "Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4", BRITISH JOURNAL OF PHARMACOLOGY, vol. 155, no. 7, 25 August 2008 (2008-08-25), pages 1066 - 1075, XP055794987, DOI: 10.1038/bjp.2008.343
SHEN, ZANCONG , YEH LI-TAIN, WALLACH KATHLEEN, ZHU NANQUN, KERR BRAD, GILLEN MICHAEL: "In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters", CLIN. DRUG INVESTIG., vol. 36, no. 6, 7 March 2016 (2016-03-07), pages 443 - 452, XP055794994, DOI: 10.1007/s40261-016-0386-y
DIETRICH KEPPLER: "Multi drug Resistance Proteins (MRPs, ABCCs): Importance for Pathophysiology and Drug Therapy", DRUG TRANSPORTERS, vol. 201, 26 October 2010 (2010-10-26), BERLIN, DE , pages 299 - 323, XP009534139, ISSN: 0171-2004, ISBN: 978-3-642-14540-7, DOI: 10.1007/978-3-642-14541-4_8
INOUE Y. ET AL., JOURNAL OF PLASTIC, RECONSTRUCTIVE & AESTHETIC SURGERY: JPRAS, vol. 63, 2010, pages 1369 - 1374
ISHIKAWA T. ET AL., FRONTIERS IN GENETICS, vol. 3, 2013, pages 306
TOYODA Y. ET AL., FASEB JOURNAL: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, vol. 23, 2009, pages 2001 - 2013
MARTIN A. ET AL., J. INVEST. DERMATOL., vol. 130, 2010, pages 529 - 540
TOYODA Y. ET AL., XENOBIOTICA, vol. 38, no. 7-8, July 2008 (2008-07-01), pages 833 - 62
TOYODA Y. ET AL., INT. J. MOL. SCI., vol. 18, 2017, pages 417
UEMURA, T. ET AL., CANCER SCI, vol. 101, no. 11, 2010, pages 2404 - 2410
TOYODA Y. ET AL., JOURNAL OF DERMATOLOGY, 2020
KHOSRAVAN R. ET AL., CLIN. PHARMACOKINET., vol. 45, 2006, pages 821 - 841
TOYODA Y. ET AL., INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, 2017, pages 417
CHEN ZS. ET AL., MOL. PHARMACOL., vol. 67, 2005, pages 545 - 557
TOYODA Y. ET AL., SCIENTIFIC REPORTS, vol. 6, 2016, pages 24586
See also references of EP 4019048A4
SHEN, ZANCONG , YEH LI-TAIN, WALLACH KATHLEEN, ZHU NANQUN, KERR BRAD, GILLEN MICHAEL: "In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters", CLIN. DRUG INVESTIG., vol. 36, no. 6, 7 March 2016 (2016-03-07), pages 443 - 452, XP055794994, DOI: 10.1007/s40261-016-0386-y
DIETRICH KEPPLER: "Multi drug Resistance Proteins (MRPs, ABCCs): Importance for Pathophysiology and Drug Therapy", DRUG TRANSPORTERS, vol. 201, 26 October 2010 (2010-10-26), BERLIN, DE , pages 299 - 323, XP009534139, ISSN: 0171-2004, ISBN: 978-3-642-14540-7, DOI: 10.1007/978-3-642-14541-4_8
INOUE Y. ET AL., JOURNAL OF PLASTIC, RECONSTRUCTIVE & AESTHETIC SURGERY: JPRAS, vol. 63, 2010, pages 1369 - 1374
ISHIKAWA T. ET AL., FRONTIERS IN GENETICS, vol. 3, 2013, pages 306
TOYODA Y. ET AL., FASEB JOURNAL: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, vol. 23, 2009, pages 2001 - 2013
MARTIN A. ET AL., J. INVEST. DERMATOL., vol. 130, 2010, pages 529 - 540
TOYODA Y. ET AL., XENOBIOTICA, vol. 38, no. 7-8, July 2008 (2008-07-01), pages 833 - 62
TOYODA Y. ET AL., INT. J. MOL. SCI., vol. 18, 2017, pages 417
UEMURA, T. ET AL., CANCER SCI, vol. 101, no. 11, 2010, pages 2404 - 2410
TOYODA Y. ET AL., JOURNAL OF DERMATOLOGY, 2020
KHOSRAVAN R. ET AL., CLIN. PHARMACOKINET., vol. 45, 2006, pages 821 - 841
TOYODA Y. ET AL., INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, 2017, pages 417
CHEN ZS. ET AL., MOL. PHARMACOL., vol. 67, 2005, pages 545 - 557
TOYODA Y. ET AL., SCIENTIFIC REPORTS, vol. 6, 2016, pages 24586
See also references of EP 4019048A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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