Title:
ACELLULAR CORNEAS, METHODS OF PRODUCING THE SAME AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/118266
Kind Code:
A1
Abstract:
A method of producing an acellular cornea includes steps of subjecting a cornea of an animal to a de-cellularization process, and has not the step of treating the cornea with a protease, a chelating agent, a detergent, a glycerol, or a combination thereof. When a native cornea is processed by the method, the native structure and conformation of the native cornea are preserved while immunogenic matters are reduced to a level that the thus produced cornea may serve as a three-dimensional scaffold for host cells to grow thereon after transplantation.
Inventors:
CHEN SHING-JYE (CN)
TSENG FAN-WEI (CN)
KU KAI-CHI (CN)
HSIEH DAR-JEN (CN)
TSENG FAN-WEI (CN)
KU KAI-CHI (CN)
HSIEH DAR-JEN (CN)
Application Number:
PCT/CN2016/109732
Publication Date:
July 13, 2017
Filing Date:
December 13, 2016
Export Citation:
Assignee:
CHEN SHING-JYE (CN)
TSENG FAN-WEI (CN)
KU KAI-CHI (CN)
HSIEH DAR-JEN (CN)
TSENG FAN-WEI (CN)
KU KAI-CHI (CN)
HSIEH DAR-JEN (CN)
International Classes:
A61L27/36
Domestic Patent References:
| WO2011031827A2 | 2011-03-17 |
Foreign References:
| CN101917932A | 2010-12-15 | |||
| US20100323440A1 | 2010-12-23 | |||
| US20130079494A1 | 2013-03-28 | |||
| CN1713894A | 2005-12-28 | |||
| CN104894062A | 2015-09-09 |
Other References:
HUANG JINLONG ET AL.: "Study of the biocompatibility on xenogeneic bone and osteoblasts in vitro", ORTHOPEDIC JOURNAL OF CHINA, vol. 22, no. 2, 15 January 2014 (2014-01-15), pages 161, XP009509556, ISSN: 1005-8478
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
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