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Title:
ACTIVE POLYPEPTIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/068550
Kind Code:
A1
Abstract:
Relates to the field of drug technology, specifically to an active polypeptide compound, which is Y-ID-X or X-ID-Y; wherein Y is a PTH/PTHrP receptor agonist or an osteoclast inhibitor; ID is a peptide bond or a linker in the molecule, which links X to Y; and X is an osteogenic growth peptide receptor agonist, a bone marrow mesenchymal stem cell irritant or a hematopoietic stem cell irritant. Also relates to a pharmaceutical composition comprising the compound, and use of the compound and the pharmaceutical composition in the preparation of a medicament for preventing, treating or alleviating diseases or disorders related to osteogenic defects or bone mineral density decreasing.

Inventors:
FU GUOQIN (CN)
Application Number:
PCT/CN2020/097017
Publication Date:
April 15, 2021
Filing Date:
June 19, 2020
Export Citation:
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Assignee:
SHAANXI MICOT TECH CO LTD (CN)
International Classes:
A61K38/16; A61K38/18; A61K38/29; A61P19/00; A61P19/08; A61P19/10
Domestic Patent References:
WO1997032594A11997-09-12
Foreign References:
CN110114065A2019-08-09
CN1403474A2003-03-19
CN104619727A2015-05-13
CN102448482A2012-05-09
US20060024267A12006-02-02
Other References:
KUNDU BIJOY, KHARE SANJAY K, SINGH GEETA: "Role of polypeptides in the treatment and diagnosis of osteoporosis", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 20, no. 4, 1 May 1999 (1999-05-01), AMSTERDAM, NL, pages 523 - 537, XP055800816, ISSN: 0196-9781, DOI: 10.1016/S0196-9781(99)00034-0
BAE CHU HYUN, KANG MYEONGMO, PARK CLARA YONGJOO, PARK BO MI, ZHANG DONGDONG, NAM HEE JIN, YANG YU-MI, SHIN DONG MIN, CHOI JE-YONG,: "A Novel Human PTH Analog [Cys25]hPTH(1–34) Restores Bone Mass in Ovariectomized Mice", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US, vol. 101, no. 10, 1 October 2016 (2016-10-01), US, pages 3700 - 3708, XP055800819, ISSN: 0021-972X, DOI: 10.1210/jc.2016-1640
KOSTENUIK,P. J.ET AL.: "OPG and PTH-(1–34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats", ENDOCRINOLOGY, vol. 142, no. 10, 31 December 2001 (2001-12-31), pages 4295 - 4304, XP002969216, DOI: 10.1210/en.142.10.4295
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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