Title:
ACTIVIN A AND/OR VPA-CONTAINING ADDITIVE FOR CULTURING NKT CELLS, AND METHOD FOR CULTURING NKT CELLS
Document Type and Number:
WIPO Patent Application WO/2020/179829
Kind Code:
A1
Abstract:
The present invention provides an additive for culturing NKT cells, said additive containing activin A and/or VPA. The present invention also provides a method for culturing NKT cells, said method comprising a step for culturing the NKT cells in a medium which contains activin A and/or VPA added thereto.
More Like This:
Inventors:
NISHIOKA KENICHI (JP)
KOSEKI HARUHIKO (JP)
KOSEKI HARUHIKO (JP)
Application Number:
PCT/JP2020/009214
Publication Date:
September 10, 2020
Filing Date:
March 04, 2020
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
C12N1/00; C12N5/0783; C07C53/128; C07K14/495
Domestic Patent References:
| WO2010027094A1 | 2010-03-11 |
Other References:
MA, C. ET AL.: "Activin A regulates activities of peripheral blood natural killer cells of mouse in an autocrine and paracrine manner", EXPERIMENTAL CELL RESEARCH, vol. 374, 2019, pages 114 - 121, XP085556927, ISSN: 0014-4827, [retrieved on 20181117], DOI: 10.1016/j.yexcr.2018.11.013
ROBSON, N. C. ET AL.: "Activin-A attenuates several human natural killer cell functions", BLOOD, vol. 113, no. 14, 2009, pages 3218 - 3225, XP055737400, ISSN: 0006-4971
HUBER, S. ET AL.: "Activin A promotes the TGF-beta- induced conversion of CD 4+ CD 25-T cells into Foxp3+ induced regulatory T cells", THE JOURNAL OF IMMUNOLOGY, vol. 182, 2009, pages 4633 - 4640, XP055387742, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0803143
HUANGFU, D. ET AL.: "Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds", NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797, XP002502536, ISSN: 1087-0156, DOI: 10.1038/NBT1418
ROBSON, N. C. ET AL.: "Activin-A attenuates several human natural killer cell functions", BLOOD, vol. 113, no. 14, 2009, pages 3218 - 3225, XP055737400, ISSN: 0006-4971
HUBER, S. ET AL.: "Activin A promotes the TGF-beta- induced conversion of CD 4+ CD 25-T cells into Foxp3+ induced regulatory T cells", THE JOURNAL OF IMMUNOLOGY, vol. 182, 2009, pages 4633 - 4640, XP055387742, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0803143
HUANGFU, D. ET AL.: "Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds", NATURE BIOTECHNOLOGY, vol. 26, no. 7, 2008, pages 795 - 797, XP002502536, ISSN: 1087-0156, DOI: 10.1038/NBT1418
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
Download PDF: