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Patent Searching and Data


Title:
ACYLGUANIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/090304
Kind Code:
A1
Abstract:
Disclosed is an excellent agent for treatment or prevention of dementia, schizophrenia and the like, which has a serotonin 5-HT5A receptor modulating activity. An acylguanidine derivative represented by formula (I), wherein guanidine is bonded to one ring of phthalene via a carbonyl group, and a cyclic group is bonded to the other ring of phthalene, is confirmed to have a strong serotonin 5-HT5A receptor modulating activity and an excellent pharmacological effect due to the serotonin 5-HT5A receptor modulating activity. Consequently, the acylguanidine derivative is useful as a good agent for treatment or prevention of dementia, schizophrenia, bipolar disorder and attention deficit hyperactivity disorder.

Inventors:
KINOYAMA ISAO (JP)
MIYAZAKI TAKEHIRO (JP)
KOGANEMARU YOHEI (JP)
SHIRAISHI NOBUYUKI (JP)
KAWAMOTO YUICHIRO (JP)
WASHIO TAKUYA (JP)
Application Number:
PCT/JP2010/051756
Publication Date:
August 12, 2010
Filing Date:
February 08, 2010
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
KINOYAMA ISAO (JP)
MIYAZAKI TAKEHIRO (JP)
KOGANEMARU YOHEI (JP)
SHIRAISHI NOBUYUKI (JP)
KAWAMOTO YUICHIRO (JP)
WASHIO TAKUYA (JP)
International Classes:
C07C279/22; A61K31/085; A61K31/167; A61K31/192; A61K31/216; A61K31/235; A61K31/277; A61K31/341; A61K31/351; A61K31/36; A61K31/366; A61K31/381; A61K31/404; A61K31/415; A61K31/423; A61K31/4245; A61K31/426; A61K31/44; A61K31/47; A61K31/472; A61K31/505; A61P25/18; A61P25/28; A61P43/00; C07D209/18; C07D213/56; C07D213/61; C07D213/64; C07D213/68; C07D213/84; C07D215/14; C07D217/02; C07D231/12; C07D231/16; C07D239/26; C07D263/56; C07D271/06; C07D271/12; C07D277/20; C07D277/30; C07D307/80; C07D309/22; C07D317/60; C07D317/62; C07D319/18; C07D333/08
Domestic Patent References:
WO2009022633A12009-02-19
Foreign References:
JP2008543886A2008-12-04
JPH1081664A1998-03-31
Other References:
See also references of EP 2394987A4
A. DE MEIJERE, F. DIEDERICH ET AL.: "Metal-Catalyzed Cross-Coupling Reactions", 1997, VCH PUBLISHERS INC.
"Courses in Experimental Chemistry", vol. 13, 2005, MARUZEN
P. G. M. WUTS, T. W. GREENE: "Green's Protective Groups in Organic Synthesis", 2006
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
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