Title:
ADAMANTANE DERIVATIVE AND USE OF SAME AS PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2018/179343
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereof, or a pharmaceutically acceptable salt thereof.
Inventors:
MORIGUCHI SHIGEKI (JP)
FUKUNAGA KOHJI (JP)
IWABUCHI YOSHIHARU (JP)
FUKUNAGA KOHJI (JP)
IWABUCHI YOSHIHARU (JP)
Application Number:
PCT/JP2017/013616
Publication Date:
October 04, 2018
Filing Date:
March 31, 2017
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07C211/27; A61K31/13; A61K31/16; A61K31/175; A61K31/18; A61K31/27; A61P3/10; A61P25/16; A61P25/28; A61P43/00; C07C211/63; C07C247/06; C07C271/14; C07C275/28; C07C311/03; C07C311/16
Other References:
MORIGUCHI,S. ET AL.: "Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy", MOLECULAR PSYCHIATRY, vol. 23, no. 2, 2016, pages 211 - 221, XP055553101
LACHENICHT,S. ET AL.: "Synthesis of Modified 4H-1, 2,4-Benzothiadiazine-1,1-dioxides and Determination of their Affinity and Selectivity for Different Types of KATP Channels", CHEMMEDCHEM, vol. 4, no. 11, 2009, pages 1850 - 1858, XP055553106
TERAMOTO,N.: "Pharmacological Profile of U- 37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K+ Channels", CARDIOVASCULAR DRUG REVIEWS, vol. 24, no. 1, 2006, pages 25 - 32, XP055553127
LACHENICHT,S. ET AL.: "Synthesis of Modified 4H-1, 2,4-Benzothiadiazine-1,1-dioxides and Determination of their Affinity and Selectivity for Different Types of KATP Channels", CHEMMEDCHEM, vol. 4, no. 11, 2009, pages 1850 - 1858, XP055553106
TERAMOTO,N.: "Pharmacological Profile of U- 37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K+ Channels", CARDIOVASCULAR DRUG REVIEWS, vol. 24, no. 1, 2006, pages 25 - 32, XP055553127
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
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