Title:
ADENOSINE A3 RECEPTOR AGONIST, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143740
Kind Code:
A1
Abstract:
Provided are a compound having both regulatory or agonist effects on adenosine A3 receptor activity, a method for preparing the series of compounds, a pharmaceutical composition of the series of compounds, and the medical use of the series of compounds. The series of compounds can be used as an efficient adenosine A3 receptor agonist, and have various pharmacological activities such as anti-tumor activity, anti-inflammatory activity, analgesic activity, neuroprotection, myocardial protection, eye disease treatment and anti-infection activity.
More Like This:
Inventors:
HU CHONGBO (CN)
YE JINQI (CN)
PAN SHUHUA (CN)
HU NING (CN)
PAN TINGTING (CN)
ZHAO LONG (CN)
CHEN ZHENGSHU (CN)
SUN SANXING (CN)
YE JINQI (CN)
PAN SHUHUA (CN)
HU NING (CN)
PAN TINGTING (CN)
ZHAO LONG (CN)
CHEN ZHENGSHU (CN)
SUN SANXING (CN)
Application Number:
PCT/CN2021/142384
Publication Date:
July 07, 2022
Filing Date:
December 29, 2021
Export Citation:
Assignee:
ZHEJIANG VIMGREEN PHARMACEUTICALS LTD (CN)
International Classes:
C07H19/16; A61K31/70; A61P29/00; A61P35/00; C07D473/34
Domestic Patent References:
| WO2020247546A1 | 2020-12-10 |
Foreign References:
| US20200115404A1 | 2020-04-16 | |||
| CN1538972A | 2004-10-20 | |||
| US20040116376A1 | 2004-06-17 | |||
| US20090156544A1 | 2009-06-18 | |||
| CN101472925A | 2009-07-01 | |||
| CN108697719A | 2018-10-23 |
Other References:
COSYN, LIESBET; PALANIAPPAN, KRISHNAN K.; KIM, SOO-KYUNG; DUONG, HENG T.; GAO, ZHAN-GUO; JACOBSON, KENNETH A.; VAN CALENBERGH, SER: "2-Triazole-Substituted Adenosines: A New Class of Selective A3 Adenosine Receptor Agonists, Partial Agonists, and Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 49, no. 25, 14 December 2006 (2006-12-14), US , pages 7373 - 7383, XP009132900, ISSN: 0022-2623, DOI: 10.1021/jm0608208
WANGJUNLI ET AL., MEDICAL RECAPITULATE, vol. 14, no. 12, 2008, pages 3585 - 3587
XIONG HONGYAN ET AL., J. CHINESE JOURNAL OF EXTRACORPOREAL CIRCULATION, vol. 14, no. 3, 2016, pages 172 - 176
REN TIANHUA ET AL., INTERNATIONAL JOURNAL OF DIGESTIVE DISEASES, vol. 38, no. 6, 2018, pages 407 - 412
BAR-YEHUDA ET AL., ARTHRITIS RHEUM, vol. 60, 2009, pages 3061 - 3071
GESSI ET AL., CLIN. CANCER RES., vol. 210, 2004, pages 4472 - 4479
OCHAION ET AL., CELL. IMMUNOL., vol. 258, 2009, pages 115 - 122
JACOBSON ET AL., PAIN, vol. 161, 2020, pages 1425 - 1441
MULLOY ET AL., ANN. THORAC. SURG., vol. 95, no. 5, 2013, pages 1762 - 7
BERGE ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
WANGJUNLI ET AL., MEDICAL RECAPITULATE, vol. 14, no. 12, 2008, pages 3585 - 3587
XIONG HONGYAN ET AL., J. CHINESE JOURNAL OF EXTRACORPOREAL CIRCULATION, vol. 14, no. 3, 2016, pages 172 - 176
REN TIANHUA ET AL., INTERNATIONAL JOURNAL OF DIGESTIVE DISEASES, vol. 38, no. 6, 2018, pages 407 - 412
BAR-YEHUDA ET AL., ARTHRITIS RHEUM, vol. 60, 2009, pages 3061 - 3071
GESSI ET AL., CLIN. CANCER RES., vol. 210, 2004, pages 4472 - 4479
OCHAION ET AL., CELL. IMMUNOL., vol. 258, 2009, pages 115 - 122
JACOBSON ET AL., PAIN, vol. 161, 2020, pages 1425 - 1441
MULLOY ET AL., ANN. THORAC. SURG., vol. 95, no. 5, 2013, pages 1762 - 7
BERGE ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
Download PDF:
Previous Patent: LENS PROTECTION COVER AND PHOTOGRAPHING APPARATUS
Next Patent: STORAGE DEVICE MANAGEMENT METHOD, DEVICE, AND STORAGE SYSTEM
Next Patent: STORAGE DEVICE MANAGEMENT METHOD, DEVICE, AND STORAGE SYSTEM