Title:
ADENOSINE DERIVATIVE HAVING ANTAGONISTIC ACTION ON A2A AND A3 ADENOSINE RECEPTORS AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2022/203427
Kind Code:
A1
Abstract:
The present invention relates to: an adenosine derivative capable of acting as an antagonist on A2A and A3 adenosine receptors through the introduction of substituents into carbons at the 2nd and 8th positions and 6th and/or 9th amine(s); a pharmaceutical composition comprising same; and a method for preparing same. The adenosine derivative regulates the activity of an A2A or A3 adenosine receptor, and thus can effectively prevent or treat brain diseases, cardiovascular diseases, sleep disorders, inflammation, immune system diseases and the like in which the receptors are involved.
Inventors:
LEE HYUK WOO (KR)
SON SEO HYUN (KR)
KANG JI YOON (KR)
JANG HYU JEONG (KR)
AHN SANG YEOP (KR)
KIM JI WON (KR)
BYUN JOON SEOK (KR)
JI SEUNG HEE (KR)
KIM SEO HYUN (KR)
CHOI JONG RYOUL (KR)
SON SEO HYUN (KR)
KANG JI YOON (KR)
JANG HYU JEONG (KR)
AHN SANG YEOP (KR)
KIM JI WON (KR)
BYUN JOON SEOK (KR)
JI SEUNG HEE (KR)
KIM SEO HYUN (KR)
CHOI JONG RYOUL (KR)
Application Number:
PCT/KR2022/004147
Publication Date:
September 29, 2022
Filing Date:
March 24, 2022
Export Citation:
Assignee:
FUTURE MEDICINE CO LTD (KR)
HK INNO N CORP (KR)
HK INNO N CORP (KR)
International Classes:
C07H19/16; A61K31/7076; A61P25/00; A61P29/00; C07H1/00
Domestic Patent References:
| WO2002070534A1 | 2002-09-12 |
Foreign References:
| KR20120103313A | 2012-09-19 | |||
| KR20100029002A | 2010-03-15 |
Other References:
HARADA HITOSHI, ET AL.: "2-alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists:their synthesis and structure-activity relationships toward hepatic glucose production induced vai agonism of the A2B receptor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 44, no. 2, 1 January 2001 (2001-01-01), US , pages 170 - 179, XP002904618, ISSN: 0022-2623, DOI: 10.1021/jm990499b
ERICA W. VAN TILBURG, ET AL.: "2,8-DISUBSTITUTED ADENOSINE DERIVATIVES AS PARTIAL AGONISTS FOR THE ADENOSINE A2A RECEPTOR", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 11, 1 January 2003 (2003-01-01), AMSTERDAM, NL, pages 2183 - 2192, XP002439399, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(03)00123-8
ERICA W. VAN TILBURG, ET AL.: "2,8-DISUBSTITUTED ADENOSINE DERIVATIVES AS PARTIAL AGONISTS FOR THE ADENOSINE A2A RECEPTOR", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 11, 1 January 2003 (2003-01-01), AMSTERDAM, NL, pages 2183 - 2192, XP002439399, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(03)00123-8
Attorney, Agent or Firm:
YOUNGBEE INTELLECTUAL PROPERTY (KR)
Download PDF: