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Title:
AGE PRODUCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/099570
Kind Code:
A1
Abstract:
Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains an extract of cherry (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active ingredient. The AGE production inhibitor or the like contains, as an active ingredient, at least one compound that is selected from the group consisting of 1-O-(E)-caffeoyl-β-D-glucopyranoside, 1-O-(E)-coumaroyl-β-D-glucopyranoside, 1-O-(E)-cinnamoyl-β-D-glucopyranoside, kaempferol 3-O-β-D-glucopyranoside, quercetin 3-O-β-D-glucopyranoside, kaempferol 3-O-(6"-malonyl)-β-D-glucopyranoside, and quercetin 3-O-(6"-malonyl)-β-D-glucopyranoside.

Inventors:
SHIMODA HIROSHI (JP)
WATANABE TAKASHI (JP)
MURAI HIROMICHI (JP)
YOSHIKAWA MASAYUKI (JP)
Application Number:
PCT/JP2011/052905
Publication Date:
August 18, 2011
Filing Date:
February 10, 2011
Export Citation:
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Assignee:
ORYZA OIL & FAT CHEM (JP)
SHIMODA HIROSHI (JP)
WATANABE TAKASHI (JP)
MURAI HIROMICHI (JP)
YOSHIKAWA MASAYUKI (JP)
International Classes:
A61K36/73; A23L1/30; A61K8/60; A61K8/97; A61K31/7024; A61K31/7048; A61K36/00; A61P3/10; A61P9/10; A61P13/12; A61P25/00; A61P27/02; A61P43/00; A61Q19/00; C07H13/04; C07H17/07
Domestic Patent References:
WO2009007412A22009-01-15
Foreign References:
JP2003012489A2003-01-15
JP2007119430A2007-05-17
JPH08245409A1996-09-24
JP2009096731A2009-05-07
JP2002220334A2002-08-09
JP2004217544A2004-08-05
JP2009545604A2009-12-24
Other References:
TOSHIHIRO NOHARA ET AL.: "Ohi, Hana, Ha no Seibun ni Tsuite", THE JAPANESE SOCIETY OF PHARMACOGNOSY NENKAI KOEN YOSHISHU, vol. 56, 2009, pages 191
YOO NAM HEE ET AL.: "Erigeroflavanone, a Flavanone Derivative from the Flowers of Erigeron annuus with Protein Glycation and Aldose Reductase Inhibitory Activity", J NAT PROD, vol. 71, no. 4, 2008, pages 713 - 715
DATABASE CAPLUS NOSHITA, TOSHIRO ET AL.: "Isolation of ethyl caffeate from the petals of Prunus yedoensis", accession no. STN Database accession no. 2006:751732
DATABASE CAPLUS OSTROWSKA, B. ET AL.: "Flavonyl glycosides from the flowers of Padus avium", accession no. STN Database accession no. 1972:70196
DATABASE CAPLUS JUNG, HYUN AH ET AL.: "In vitro antioxidant activity of some selected Prunus species in Korea", accession no. STN Database accession no. 2003:12258
ORIZA YUKA: "Ko Toka Sokyu no Ogata Biyoyaku 'Sakura no Hana' o Joshi e", NEWS RELEASE, 23 February 2010 (2010-02-23), pages 1 - 5
Attorney, Agent or Firm:
KUMAZAKI Yoichi (JP)
Yoichi Kumazaki (JP)
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Claims: