Title:
AGENT FOR AMELIORATING AND/OR PREVENTING SICKLE CELL DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/054473
Kind Code:
A1
Abstract:
The present invention provides: an agent that is for ameliorating and/or preventing sickle cell disease and that contains 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt thereof; and amelioration and/or prevention of sickle cell disease by using said agent.
Inventors:
TANI KENZABURO (JP)
SODA YASUSHI (JP)
LIAO JIYUAN (JP)
MIYAMOTO SHOHEI (JP)
KAWATA SATOFUMI (JP)
TOMIOKA MOTOYASU (JP)
KODAMA KEN (JP)
SODA YASUSHI (JP)
LIAO JIYUAN (JP)
MIYAMOTO SHOHEI (JP)
KAWATA SATOFUMI (JP)
TOMIOKA MOTOYASU (JP)
KODAMA KEN (JP)
Application Number:
PCT/JP2020/035616
Publication Date:
March 25, 2021
Filing Date:
September 18, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
NEOPHARMA JAPAN CO LTD (JP)
NEOPHARMA JAPAN CO LTD (JP)
International Classes:
A61P7/00; A61K31/197; A61K31/28; A61K31/295; A61K31/315; A61K33/06; A61K33/24; A61K33/26; A61K33/30; A61K33/34; A61P43/00
Domestic Patent References:
WO2000018418A2 | 2000-04-06 | |||
WO2004073623A2 | 2004-09-02 | |||
WO2011145343A1 | 2011-11-24 | |||
WO2013054755A1 | 2013-04-18 |
Other References:
OSEGHALE, ALUYA R. ET AL.: "Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and beta -YAC transgenic mice", BLOOD CELLS, MOLECULES AND DISEASES, vol. 79, no. 102345, 9 July 2019 (2019-07-09), pages 1 - 8, XP085811345, ISSN: 1079-9796, DOI: 10.1016/j.bcmd.2019.102345
REPHAELI, ADA ET AL.: "Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin- independent manner", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, 2016, pages 91 - 97, XP029637464, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2016.06.004
NATURE REVIEWS DRUG DISCOVERY, vol. 19, no. 2, 2019, pages 139 - 158
LANCET., vol. 388, no. 10053, 2016, pages 1459 - 1544
LANCET., vol. 386, no. 9995, 2015, pages 743 - 800
BLOOD ADVANCES., vol. 4, no. 5, 2020, pages 793 - 802
CLINICA CHIMICA ACTA, vol. 458, 2016, pages 99 - 102
See also references of EP 4032587A4
REPHAELI, ADA ET AL.: "Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin- independent manner", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, 2016, pages 91 - 97, XP029637464, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2016.06.004
NATURE REVIEWS DRUG DISCOVERY, vol. 19, no. 2, 2019, pages 139 - 158
LANCET., vol. 388, no. 10053, 2016, pages 1459 - 1544
LANCET., vol. 386, no. 9995, 2015, pages 743 - 800
BLOOD ADVANCES., vol. 4, no. 5, 2020, pages 793 - 802
CLINICA CHIMICA ACTA, vol. 458, 2016, pages 99 - 102
See also references of EP 4032587A4
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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