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Patent Searching and Data


Title:
AGENT FOR AMELIORATING AND/OR PREVENTING SICKLE CELL DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/054473
Kind Code:
A1
Abstract:
The present invention provides: an agent that is for ameliorating and/or preventing sickle cell disease and that contains 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt thereof; and amelioration and/or prevention of sickle cell disease by using said agent.

Inventors:
TANI KENZABURO (JP)
SODA YASUSHI (JP)
LIAO JIYUAN (JP)
MIYAMOTO SHOHEI (JP)
KAWATA SATOFUMI (JP)
TOMIOKA MOTOYASU (JP)
KODAMA KEN (JP)
Application Number:
PCT/JP2020/035616
Publication Date:
March 25, 2021
Filing Date:
September 18, 2020
Export Citation:
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Assignee:
UNIV TOKYO (JP)
NEOPHARMA JAPAN CO LTD (JP)
International Classes:
A61P7/00; A61K31/197; A61K31/28; A61K31/295; A61K31/315; A61K33/06; A61K33/24; A61K33/26; A61K33/30; A61K33/34; A61P43/00
Domestic Patent References:
WO2000018418A22000-04-06
WO2004073623A22004-09-02
WO2011145343A12011-11-24
WO2013054755A12013-04-18
Other References:
OSEGHALE, ALUYA R. ET AL.: "Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and beta -YAC transgenic mice", BLOOD CELLS, MOLECULES AND DISEASES, vol. 79, no. 102345, 9 July 2019 (2019-07-09), pages 1 - 8, XP085811345, ISSN: 1079-9796, DOI: 10.1016/j.bcmd.2019.102345
REPHAELI, ADA ET AL.: "Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin- independent manner", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 91, 2016, pages 91 - 97, XP029637464, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2016.06.004
NATURE REVIEWS DRUG DISCOVERY, vol. 19, no. 2, 2019, pages 139 - 158
LANCET., vol. 388, no. 10053, 2016, pages 1459 - 1544
LANCET., vol. 386, no. 9995, 2015, pages 743 - 800
BLOOD ADVANCES., vol. 4, no. 5, 2020, pages 793 - 802
CLINICA CHIMICA ACTA, vol. 458, 2016, pages 99 - 102
See also references of EP 4032587A4
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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