Title:
AGENT FOR TREATING OR PREVENTING CEREBROVASCULAR DEMENTIA
Document Type and Number:
WIPO Patent Application WO/2021/029346
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a cell preparation for treating or preventing cerebrovascular dementia. The present invention provides a cell preparation for treating or preventing cerebrovascular dementia, the cell preparation including a SSEA-3 positive pluripotent stem cell (muse cell) derived from mesenchymal tissue or cultured mesenchymal tissue of a living body.
Inventors:
NIIZUMA KUNIYASU (JP)
TOMINAGA TEIJI (JP)
TOMINAGA TEIJI (JP)
Application Number:
PCT/JP2020/030330
Publication Date:
February 18, 2021
Filing Date:
August 07, 2020
Export Citation:
Assignee:
UNIV TOHOKU (JP)
LIFE SCIENCE INST INC (JP)
LIFE SCIENCE INST INC (JP)
International Classes:
A61K35/545; A61K35/28; A61P25/28; C12N5/0775
Domestic Patent References:
| WO2017199976A1 | 2017-11-23 | |||
| WO2018021515A1 | 2018-02-01 | |||
| WO2017188457A1 | 2017-11-02 | |||
| WO2011007900A1 | 2011-01-20 |
Foreign References:
| JP2018111722A | 2018-07-19 | |||
| JP5185443B2 | 2013-04-17 | |||
| JP2018111722A | 2018-07-19 |
Other References:
NAKAZAKI, M. ET AL.: "Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model.", NEUROSCIENCE, vol. 408, April 2019 (2019-04-01), pages 361 - 377, XP085707923, DOI: 10.1016/j.neuroscience.2019.04.018
KONG, D. ET AL.: "Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia.", NEUROSCIENCE LETTERS, vol. 637, 2017, pages 175 - 181, XP029873491, DOI: 10.1016/j.neulet.2016.11.024
TAGUCHI, AKIHIKO; YAMAHARA, KENICHI: "The specificity of cerebrovascular architecture and dementia 8) Dementia treatment strategy by regenerative medicine targeting the cerebral vessel", VASCULAR BIOLOGY & MEDICINE, vol. 15, no. 1, 30 November 2013 (2013-11-30), JP , pages 69 - 74, XP009534402, ISSN: 1345-9031
OGURA, F. ET AL., STEM CELLS DEV., 17 January 2014 (2014-01-17)
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 36, no. 9, 2016, pages 1592 - 1602
KONG, D. ET AL.: "Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia.", NEUROSCIENCE LETTERS, vol. 637, 2017, pages 175 - 181, XP029873491, DOI: 10.1016/j.neulet.2016.11.024
TAGUCHI, AKIHIKO; YAMAHARA, KENICHI: "The specificity of cerebrovascular architecture and dementia 8) Dementia treatment strategy by regenerative medicine targeting the cerebral vessel", VASCULAR BIOLOGY & MEDICINE, vol. 15, no. 1, 30 November 2013 (2013-11-30), JP , pages 69 - 74, XP009534402, ISSN: 1345-9031
OGURA, F. ET AL., STEM CELLS DEV., 17 January 2014 (2014-01-17)
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 36, no. 9, 2016, pages 1592 - 1602
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
Download PDF: