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Title:
ALKOXYPHENYL DERIVATIVE, NUCLEOSIDE PROTECTOR, NUCLEOTIDE PROTECTOR, METHOD FOR PRODUCING OLIGONUCLEOTIDE, AND METHOD FOR REMOVING SUBSTITUENT
Document Type and Number:
WIPO Patent Application WO/2020/017085
Kind Code:
A1
Abstract:
The present invention pertains to: an alkoxyphenyl derivative with which oligonucleotides can by synthesized by a liquid-phase synthesis method easier and faster than conventional methods; a nucleoside protector and a nucleotide protector to which the alkoxyphenyl derivative binds; a method for producing an oligonucleotide using same; and a method for selectively removing the alkoxyphenyl derivative moiety. Provided is a compound represented by general formula (1) or a derivative thereof. (In the formula, each R independently represents a C10-40 alkyl group which may be substituted or unsubstituted. m represents an integer of 1-5. When m is 2 or more, the plurality of RO's may be identical or different. X represents O, S, NH, or NRN. n represents an integer of 1-4. RN represents a C1-6 alkyl group which may be substituted or unsubstituted.)

Inventors:
CHIBA KAZUHIRO (JP)
OKADA YOHEI (JP)
UMEMOTO HIDEAKI (JP)
ONAKA TAKUYA (JP)
Application Number:
PCT/JP2019/008113
Publication Date:
January 23, 2020
Filing Date:
March 01, 2019
Export Citation:
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Assignee:
FUJIMOTO CHEMICALS CO LTD (JP)
International Classes:
C07C69/78; C07C69/92; C07C235/52; C07D413/04; C07D473/18; C07F9/6558; C07F9/6561; C07H19/073; C07H19/10; C07H19/173; C07H19/20
Domestic Patent References:
WO2004081979A22004-09-23
WO1999019276A21999-04-22
WO2005118542A12005-12-15
WO2012157723A12012-11-22
WO2012157723A12012-11-22
Foreign References:
JP2004262809A2004-09-24
US5298652A1994-03-29
JP2007536200A2007-12-13
JPS49126644A1974-12-04
JPS49124043A1974-11-27
JP2010275254A2010-12-09
US5548852A1996-08-27
Other References:
S. L. BEAUCAGED. E. BERGSTORMG. D. GLICKR. A. JONES: "Current Protocols in Nucleic Acid Chemistry", 2000, JOHN WILEY&SONS
"Genome Chemistry-A Scientific Approach Utilizing Artificial Nucleic Acids", 2003, KOUDANSHA SCIENTIFIC CO., LTD.
C. -H.CHEN ET AL., AUST.J. CHEM., vol. 63, 2010, pages 227 - 235
Y. MATSUNO ET AL., ORG. LETT., vol. 18, 2016, pages 800 - 803
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
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