Title:
ALPHA-AMINOAMIDE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2016/052928
Kind Code:
A1
Abstract:
The present invention relates to an alpha-aminoamide derivative compound and a pharmaceutical composition comprising the same. According to various embodiments of the present invention, provided is a therapeutic agent which can overcome the disadvantages of conventional drugs used as a MAO-B inhibitor and, more specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of conventional drugs by irreversibly acting via a covalent bond with MAO-B to exhibit a therapeutic effect. Particularly, a new compound may be provided having superior stability and efficacy compared to a conventional reversible MAO-B inhibitor.
Inventors:
PARK KI DUK (KR)
LEE CHANG JOON (KR)
KIM DONG JIN (KR)
PAE AE NIM (KR)
CHOO HYUN AH (KR)
MIN SUN JOON (KR)
KANG YONG KOO (KR)
KIM YUN KYUNG (KR)
SONG HYO JUNG (KR)
CHOI JI WON (KR)
NAM MIN HO (KR)
HEO JUN YOUNG (KR)
YEON SEUL KI (KR)
JANG BO KO (KR)
JU EUN JI (KR)
JO SEON MI (KR)
LEE CHANG JOON (KR)
KIM DONG JIN (KR)
PAE AE NIM (KR)
CHOO HYUN AH (KR)
MIN SUN JOON (KR)
KANG YONG KOO (KR)
KIM YUN KYUNG (KR)
SONG HYO JUNG (KR)
CHOI JI WON (KR)
NAM MIN HO (KR)
HEO JUN YOUNG (KR)
YEON SEUL KI (KR)
JANG BO KO (KR)
JU EUN JI (KR)
JO SEON MI (KR)
Application Number:
PCT/KR2015/010104
Publication Date:
April 07, 2016
Filing Date:
September 24, 2015
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C07C237/20; A61K31/16; A61K31/167; C07C231/12; C07C237/04; C07C309/04
Foreign References:
| US5391577A | 1995-02-21 | |||
| US8283380B2 | 2012-10-09 |
Other References:
PEVARELLO, PAOLO ET AL.: "Synthesis and anticonvulsant activity of a new class of 2-[(arylalkyl)amino]alkanamide derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, 28 January 1998 (1998-01-28), pages 579 - 590, XP002101390, DOI: doi:10.1021/jm970599m
DHINGRA, DINESH ET AL.: "Inhibition of MAO and GABA: Probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 46, April 2008 (2008-04-01), pages 212 - 218
LEONETTI, FRANCE SCO ET AL.: "Solid-synthesis and insights into structure-activity relationship of safinamide analogues as potent and sleetive inhibitors of type B monoamine oxidase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, 7 September 2007 (2007-09-07), pages 4909 - 4916
See also references of EP 3202759A4
DHINGRA, DINESH ET AL.: "Inhibition of MAO and GABA: Probable mechanisms for antidepressant-like activity of Nardostachys jatamansi DC. in mice", INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 46, April 2008 (2008-04-01), pages 212 - 218
LEONETTI, FRANCE SCO ET AL.: "Solid-synthesis and insights into structure-activity relationship of safinamide analogues as potent and sleetive inhibitors of type B monoamine oxidase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, 7 September 2007 (2007-09-07), pages 4909 - 4916
See also references of EP 3202759A4
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
특허법인 충현 (KR)
특허법인 충현 (KR)
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