Title:
AMIDE DERIVATIVE COMPRISING PROBENECID AND ARGININE, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2021/246779
Kind Code:
A1
Abstract:
The present invention relates to an amide derivative synthesized using probenecid and arginine as reactants, a pharmaceutical composition comprising same for preventing, ameliorating, or treating heart failure, and a method for synthesizing the amide derivative.
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Inventors:
OH JOO-HYUNG (KR)
OH SEUNG-YAE (KR)
CHOI BYUNG-IL (US)
RUBINSTEIN JACK (US)
OH SEUNG-YAE (KR)
CHOI BYUNG-IL (US)
RUBINSTEIN JACK (US)
Application Number:
PCT/KR2021/006880
Publication Date:
December 09, 2021
Filing Date:
June 02, 2021
Export Citation:
Assignee:
SAMOH FARM CO LTD (KR)
International Classes:
C07C311/16; A61K31/166; A61P9/04; A61P9/12; A61P11/00; A61P15/10; A61P19/06; A61P21/00; C07C279/14
Foreign References:
| US20130046021A1 | 2013-02-21 | |||
| US20120295910A1 | 2012-11-22 | |||
| JP2016512564A | 2016-04-28 |
Other References:
MOLLICA ADRIANO, ROBERTO COSTANTE , ATILLA AKDEMIR , SIMONE CARRADORI , AZZURRA STEFANUCCI , GIORGIA MACEDONIO , MARIANGELA CERUS: "Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 17, 1 September 2015 (2015-09-01), AMSTERDAM, NL, pages 5311 - 5318, XP055879281, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2015.07.066
CARRADORI SIMONE; MOLLICA ADRIANO; CERUSO MARIANGELA; D’ASCENZIO MELISSA; DE MONTE CELESTE; CHIMENTI PAOLA; SABIA ROCCHINA; : "New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 13, 14 May 2015 (2015-05-14), AMSTERDAM, NL, pages 2975 - 2981, XP029170497, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2015.05.013
CARRADORI SIMONE; MOLLICA ADRIANO; CERUSO MARIANGELA; D’ASCENZIO MELISSA; DE MONTE CELESTE; CHIMENTI PAOLA; SABIA ROCCHINA; : "New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 13, 14 May 2015 (2015-05-14), AMSTERDAM, NL, pages 2975 - 2981, XP029170497, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2015.05.013
Attorney, Agent or Firm:
HANYANG PATENT FIRM (KR)
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