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Title:
AMIDITE COMPOUND AND METHOD FOR PRODUCING POLYNUCLEOTIDE USING SAID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/208571
Kind Code:
A1
Abstract:
The present invention provides: an amidite compound represented by formula (1), which enables synthesis of RNA with high purity; and a method for producing a polynucleotide, which uses this compound. (In the formula, R represents a group of (2) (wherein Ra and Rb moieties may be the same as or different from each other, and each represents a methyl group, an ethyl group or a hydrogen atom, provided that the Ra and Rb moieties do not represent hydrogen atoms at the same time; and n represents an integer of 1-5), Ba moiety represents an optionally protected group having a nucleobase skeleton; G1 and G2 moieties may be the same as or different from each other, and each represents a protecting group of a hydroxyl group; and G3 moieties may be the same as or different from each other, and each represents an alkyl group.)

Inventors:
TANAKA YUKI (JP)
SAITO TATSUYA (JP)
IHARA HIDEKI (JP)
Application Number:
PCT/JP2019/017249
Publication Date:
October 31, 2019
Filing Date:
April 23, 2019
Export Citation:
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Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07H19/10; C07F9/6558; C07H19/20; C07H21/02
Domestic Patent References:
WO2012073857A12012-06-07
WO2011034072A12011-03-24
WO2013027843A12013-02-28
WO2017188042A12017-11-02
Foreign References:
JP2016050203A2016-04-11
JP2018083148A2018-05-31
JP2018141559A2018-09-13
JP5157168B22013-03-06
JP5554881B22014-07-23
CN107602497A2018-01-19
JP2016050203A2016-04-11
US20120035246A12012-02-09
Other References:
CHEMICAL COMMUNICATIONS, vol. 47, no. 12, 2011, pages 3613
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 100, no. 3, 2016, pages 1241
JOURNAL OF ORGANIC CHEMISTRY, vol. 75, no. 21, 2010, pages 7092
TETRAHEDRON LETTERS, vol. 46, 2005, pages 2961
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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