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Title:
AMINO ACID-DERIVED CYCLIC PHOSPHONAMIDES AND METHODS OF SYNTHESIZING THE SAME
Document Type and Number:
WIPO Patent Application WO2002014344
Kind Code:
A3
Abstract:
New phosphonamide compounds and methods of forming those compounds are provided. In one embodiment, the inventive methods comprise subjecting an opened-ring phosphonamide template to a ring-closing metathesis reaction in the presence of a ring-closing catalyst (e.g., a Grubbs catalyst) to yield a phosphonamide. In another embodiment, the inventive methods comprise reacting a template structure with a phosphorus (III) compound to yield the phosphonamide. Advantageously, in either embodiment, the template structures can be provided with a wide array of functional groups (e.g., amino acid side chains, peptides) chosen to provide particular properties to the compound.

Inventors:
HANSON PAUL R
SPROTT KEVIN T
MCREYNOLDS MATTHEW D
Application Number:
PCT/US2001/041606
Publication Date:
September 06, 2002
Filing Date:
August 06, 2001
Export Citation:
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Assignee:
UNIV KANSAS (US)
International Classes:
B01J31/24; C07B61/00; C07C213/08; C07C217/10; C07F9/24; C07F9/26; C07F9/6584; (IPC1-7): C07F9/22; C07F9/36; C07F9/572; C07F9/645
Other References:
SPROTT ET AL.: "The synthetic of P-chiral amino acid-derived phosphonamidic anhydrides", J. ORG. CHEM., vol. 65, no. 15, 6 July 2000 (2000-07-06), pages 4721 - 4728, XP002909793
SPROTT ET AL.: "The synthesis of sterically demanding amino acid-derived cyclic phosphonamides", J. ORG. CHEM., vol. 65, no. 23, 25 October 2000 (2000-10-25), pages 7913 - 7918, XP002909795
SPROTT ET AL.: "Ring-closing metathesis strategies to amino acid-derived P-heterocycles", SYNTHESIS, vol. 4, 2001, pages 612 - 620, XP002909794
SLATER ET AL.: "Antimalarial activity of unsaturated putrescine derivatives", ANN. TROP. MED. PARASITOL, vol. 92, no. 3, 1998, pages 271 - 277, XP002909796
See also references of EP 1311515A4
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