Title:
AMINOALKYL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/156074
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound for the treatment and/or prevention of pain, which has excellent skin penetrability and is less irritative to the skin. The means for solving the problem is a compound of formula (I) or a pharmacologically acceptable salt thereof.
(In formula (I), R1 is a methyl group, etc., R2 is a fluorine atom, etc., R3 is a methyl group, etc., R4 is a methyl group, etc., and R5 is a methyl group, etc.)
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Inventors:
SUZUKI KEISUKE (JP)
Application Number:
PCT/JP2019/004071
Publication Date:
August 15, 2019
Filing Date:
February 05, 2019
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07D309/06; A61K9/70; A61K31/351; A61P25/04; A61P29/00; A61P35/00; C07D309/08
Foreign References:
| JPH0931033A | 1997-02-04 | |||
| JP2009507875W |
Other References:
FRITZ EIDEN ,MICHAEL SCHMIDT: "ZNS active phenylpyrans: 3-(dimethylaminomethyl)-4-(3-methoxyphenyl)tetrahydro-4-pyra nol and -4-thiopyranol", ARCHIV DER PHARMAZIE, vol. 320, 1987, pages 1099 - 1103, XP055718504
BRITISH JOURNAL OF PHARMACOLOGY, vol. 172, 2015, pages 2179 - 2209
AM J CLIN DERMATOL, vol. 1, 2000, pages 361 - 368
THER DELIV., vol. 1, no. 1, July 2010 (2010-07-01), pages 109 - 131
CLINICAL, COSMETIC AND INVESTIGATIONAL DERMATOLOGY, vol. 10, 2017, pages 289 - 298
DERMATOL SURG, vol. 0, 2017, pages 1 - 8
CURR MED RES OPIN., vol. 22, no. 3, March 2006 (2006-03-01), pages 501 - 509
CUTAN OCUL TOXICOL., vol. 29, no. 4, December 2010 (2010-12-01), pages 241 - 246
CONTACT DERMATITIS., vol. 59, no. 6, December 2008 (2008-12-01), pages 366 - 369
MOLECULES, vol. 23, 2018, pages 681
"Publication Department of Medical Books", 5 April 2018, SHINKO TRADING CO., LTD., article "Health, Labor and Welfare Policy Grants (Research on Chronic Pain),''Research on Constructing a System for the Treatment and Education of Chronic Pain Problems"
GENERAL HOSPITAL PSYCHIATRY, vol. 31, 2009, pages 206 - 219
See also references of EP 3750883A4
BRITISH JOURNAL OF PHARMACOLOGY, vol. 172, 2015, pages 2179 - 2209
AM J CLIN DERMATOL, vol. 1, 2000, pages 361 - 368
THER DELIV., vol. 1, no. 1, July 2010 (2010-07-01), pages 109 - 131
CLINICAL, COSMETIC AND INVESTIGATIONAL DERMATOLOGY, vol. 10, 2017, pages 289 - 298
DERMATOL SURG, vol. 0, 2017, pages 1 - 8
CURR MED RES OPIN., vol. 22, no. 3, March 2006 (2006-03-01), pages 501 - 509
CUTAN OCUL TOXICOL., vol. 29, no. 4, December 2010 (2010-12-01), pages 241 - 246
CONTACT DERMATITIS., vol. 59, no. 6, December 2008 (2008-12-01), pages 366 - 369
MOLECULES, vol. 23, 2018, pages 681
"Publication Department of Medical Books", 5 April 2018, SHINKO TRADING CO., LTD., article "Health, Labor and Welfare Policy Grants (Research on Chronic Pain),''Research on Constructing a System for the Treatment and Education of Chronic Pain Problems"
GENERAL HOSPITAL PSYCHIATRY, vol. 31, 2009, pages 206 - 219
See also references of EP 3750883A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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