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Patent Searching and Data


Title:
AMINOGLYCOSIDES:SYNTHESIS AND USE AS ANTIFUNGALS
Document Type and Number:
WIPO Patent Application WO/2012/082650
Kind Code:
A3
Abstract:
The present invention relates to novel aminoglycoside analogs having certain substituents at the 6 position of ring III which exhibit improved antifungal activity but possess minimal antibacterial properties. The compounds of the present invention are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.

Inventors:
CHANG CHENG-WEI TOM (US)
TAKEMOTO JON Y (US)
Application Number:
PCT/US2011/064481
Publication Date:
November 01, 2012
Filing Date:
December 12, 2011
Export Citation:
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Assignee:
UNIV UTAH STATE (US)
CHANG CHENG-WEI TOM (US)
TAKEMOTO JON Y (US)
International Classes:
C07H15/22
Domestic Patent References:
WO2005116041A22005-12-08
WO2009152202A22009-12-17
Foreign References:
US4493831A1985-01-15
US4279997A1981-07-21
Other References:
WANG, J. ET AL.: "Glycodiversification for the Optimization of the Kanamycin Class Aminoglycodides", J. MED. CHEM., vol. 48, no. 20, 2005, pages 6271 - 6285, XP055118234
See also references of EP 2651959A4
Attorney, Agent or Firm:
WESTERN, M., Wayne et al. (LLPPO Box 121, Sandy UT, US)
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