Title:
AMPHIPHILIC BLOCK COPOLYMER, ABSORBABLE BONE WAX AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/179495
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines. Disclosed are an amphiphilic block copolymer, absorbable bone wax and a preparation method therefor. In the amphiphilic block copolymer of the present invention, a hydrophilic segment is a water-soluble polyoxyethylene chain, and a hydrophobic segment is a semi-crystalline ester chain; the ester chain is a bipolymer of trimethylene carbonate and ε-caprolactone; the structural general formula of the amphiphilic block copolymer is as follows: PEG(-PTCL)n, wherein n is 1-8, the PEG is polyethylene glycol or methoxypolyethylene glycol, and the PTCL is a bipolymer of trimethylene carbonate and ε-caprolactone. In the present invention, when the amphiphilic block copolymer is used as bone wax, the amphiphilic block copolymer has the advantages of good blocking performance, rapid disintegration without space occupation, no influence on bone healing, good hand feeling operation performance, good cell compatibility, small local acidity, and easiness in stable production.
Inventors:
PAN GAOFENG (CN)
GAO JIANFENG (CN)
ZENG JINGWEN (CN)
ZHENG SHAODONG (CN)
ZHU ZHIYUAN (CN)
GAO JIANFENG (CN)
ZENG JINGWEN (CN)
ZHENG SHAODONG (CN)
ZHU ZHIYUAN (CN)
Application Number:
PCT/CN2020/099818
Publication Date:
September 16, 2021
Filing Date:
July 02, 2020
Export Citation:
Assignee:
CHENGDU EHANRI MEDICAL TECH CO LTD (CN)
BEIJING EHANRI MEDICAL TECH CO LTD (CN)
XINXIANG EHANRI MEDICAL TECH CO LTD (CN)
BEIJING EHANRI MEDICAL TECH CO LTD (CN)
XINXIANG EHANRI MEDICAL TECH CO LTD (CN)
International Classes:
C08G63/664; A61L24/00; A61L24/04; C08G63/64; C08G63/78; C08G63/85
Foreign References:
| CN111205445A | 2020-05-29 | |||
| US20170066874A1 | 2017-03-09 | |||
| US8992949B1 | 2015-03-31 | |||
| CN106039390A | 2016-10-26 | |||
| CN104353083A | 2015-02-18 | |||
| US20070218099A1 | 2007-09-20 | |||
| CN109908397A | 2019-06-21 | |||
| US20150023905A1 | 2015-01-22 |
Other References:
MIZUTANI MANABU, MATSUDA TAKEHISA: "Liquid acrylate-endcapped biodegradable poly(ε-caprolactone-co-trimethylene carbonate). I. Preparation and visible light-induced photocuring characteristics”", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 62, no. 3, 5 December 2002 (2002-12-05), pages 387 - 394, XP055846206, ISSN: 0021-9304, DOI: 10.1002/jbm.10294
DANHIER, F. ; MAGOTTEAUX, N. ; UCAKAR, B. ; LECOUTURIER, N. ; BREWSTER, M. ; PREAT, V.: "Novel self-assembling PEG-p-(CL-co-TMC) polymeric micelles as safe and effective delivery system for Paclitaxel", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 73, no. 2, 1 October 2009 (2009-10-01), pages 230 - 238, XP026652683, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2009.06.015
SUWANPRATEEB J., SUVANNAPRUK W., THAMMARAKCHAROEN F., CHOKEVIVAT W., RUKSKUL P.: "“Preparation and characterization of PEG-PPG-PEG copolymer/pregelatinized starch blends for use as resorbable bone hemostatic wax”", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, vol. 24, no. 12, 1 December 2013 (2013-12-01), pages 2881 - 2888, XP055846213, ISSN: 0957-4530, DOI: 10.1007/s10856-013-5027-x
GOU PENG-FEI, ZHU WEI-PU, SHEN ZHI-QUAN: "Drug-grafted seven-arm amphiphilic star poly(ε-caprolactone-co-carbonate)-b-poly(ethylene glycol)s based on a cyclodextrin core: synthesis and self-assembly behavior in water”", POLYMER CHEMISTRY, vol. 1, no. 8, 8 June 2010 (2010-06-08), pages 1205 - 1214, XP055846214, ISSN: 1759-9954, DOI: 10.1039/c0py00043d
DANHIER, F. ; MAGOTTEAUX, N. ; UCAKAR, B. ; LECOUTURIER, N. ; BREWSTER, M. ; PREAT, V.: "Novel self-assembling PEG-p-(CL-co-TMC) polymeric micelles as safe and effective delivery system for Paclitaxel", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 73, no. 2, 1 October 2009 (2009-10-01), pages 230 - 238, XP026652683, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2009.06.015
SUWANPRATEEB J., SUVANNAPRUK W., THAMMARAKCHAROEN F., CHOKEVIVAT W., RUKSKUL P.: "“Preparation and characterization of PEG-PPG-PEG copolymer/pregelatinized starch blends for use as resorbable bone hemostatic wax”", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, vol. 24, no. 12, 1 December 2013 (2013-12-01), pages 2881 - 2888, XP055846213, ISSN: 0957-4530, DOI: 10.1007/s10856-013-5027-x
GOU PENG-FEI, ZHU WEI-PU, SHEN ZHI-QUAN: "Drug-grafted seven-arm amphiphilic star poly(ε-caprolactone-co-carbonate)-b-poly(ethylene glycol)s based on a cyclodextrin core: synthesis and self-assembly behavior in water”", POLYMER CHEMISTRY, vol. 1, no. 8, 8 June 2010 (2010-06-08), pages 1205 - 1214, XP055846214, ISSN: 1759-9954, DOI: 10.1039/c0py00043d
Attorney, Agent or Firm:
CHENGDU JIUDING TIANYUAN INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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