Title:
AMPHIPHILIC MOLECULAR SELF-ASSEMBLY NANODRUG FOR TUMOR TREATMENT, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/156424
Kind Code:
A1
Abstract:
An amphiphilic molecular self-assembly nanodrug for tumor treatment, a preparation method therefor and a use thereof. Specifically disclosed is an amphiphilic compound, which is a conjugate of a hydrazine group-modified organic photothermal agent and a carbonyl group-containing anti-tumor drug by means of a hydrazone bond. Further disclosed is a nanoparticle, which is obtained by self-assembly of the amphiphilic compound in an aqueous solution. The nanoparticle has an anti-tumor effect, can be enriched and dissociated in a tumor region, and has the synergistic effect of a combination therapy of photothermal therapy and chemotherapy.
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Inventors:
ZHANG WEI (CN)
LIU BEN (CN)
LAI YUXIAO (CN)
LIU BEN (CN)
LAI YUXIAO (CN)
Application Number:
PCT/CN2021/137302
Publication Date:
July 28, 2022
Filing Date:
December 12, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K41/00; A61K9/14; A61K31/704; A61K45/06; A61P35/00; A61P35/02; C07H1/00; C07H15/252
Foreign References:
| CN112675305A | 2021-04-20 | |||
| CN102099059A | 2011-06-15 | |||
| CN103826625A | 2014-05-28 |
Other References:
WANG LU, ZHU XIAO, XIE CHENG, DING NING, WENG XIAOFU, LU WEIYUE, WEI XUNBIN, LI CONG: "Imaging acidosis in tumors using a pH-activated near-infrared fluorescence probe", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 48, no. 95, 1 January 2012 (2012-01-01), UK , pages 11677, XP055952321, ISSN: 1359-7345, DOI: 10.1039/c2cc36488c
HUANG GUOJIA, SI ZHAN, YANG SIHUA, LI CONG, XING DA: "Dextran based pH-sensitive near-infrared nanoprobe for in vivo differential-absorption dual-wavelength photoacoustic imaging of tumors", JOURNAL OF MATERIALS CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 22, no. 42, 1 January 2012 (2012-01-01), GB , pages 22575, XP055952325, ISSN: 0959-9428, DOI: 10.1039/c2jm33990k
YIN HUABIN, MENG TONG, SHU LING, MAO MIN, ZHOU LEI, CHEN HAIYAN, SONG DIANWEN: "Novel reduction-sensitive micellar nanoparticles assembled from Rituximab-doxorubicin conjugates as smart and intuitive drug delivery systems for the treatment of non-Hodgkin's lymphoma", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, vol. 90, no. 5, 1 November 2017 (2017-11-01), pages 892 - 899, XP055952330, ISSN: 1747-0277, DOI: 10.1111/cbdd.13010
HUANG GUOJIA, SI ZHAN, YANG SIHUA, LI CONG, XING DA: "Dextran based pH-sensitive near-infrared nanoprobe for in vivo differential-absorption dual-wavelength photoacoustic imaging of tumors", JOURNAL OF MATERIALS CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 22, no. 42, 1 January 2012 (2012-01-01), GB , pages 22575, XP055952325, ISSN: 0959-9428, DOI: 10.1039/c2jm33990k
YIN HUABIN, MENG TONG, SHU LING, MAO MIN, ZHOU LEI, CHEN HAIYAN, SONG DIANWEN: "Novel reduction-sensitive micellar nanoparticles assembled from Rituximab-doxorubicin conjugates as smart and intuitive drug delivery systems for the treatment of non-Hodgkin's lymphoma", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, vol. 90, no. 5, 1 November 2017 (2017-11-01), pages 892 - 899, XP055952330, ISSN: 1747-0277, DOI: 10.1111/cbdd.13010
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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