Title:
AMPHOTERICIN B STRUCTURED EMULSION
Document Type and Number:
WIPO Patent Application WO2001097778
Kind Code:
A3
Abstract:
Parenteral compositions of oil-coated-Amphotericin B in structured-emulsion form, having LD>50< of atleast 400mg/kg in mice and process for making the same have been described. The process essentially requires dispersing Amphotericin B in oily vehicle and dispersing emulsifier in the aqueous phase. The process of present invention is simple, cost effective and gives a stable product suitable for parenteral administration. Amphotericin B emulsion compositions prepared by the process of the present invention may be administered to human beings and animals for the treatment of fungal infections, with substantially equivalent or greater efficacy and low drug toxicity as compared to the conventional composition containing Amphotericin B and sodium desoxycholate.
Inventors:
PAI SRIKANTH ANNAPPA (IN)
KOCHAREKAR SHILPA SUDHAKAR (IN)
KOCHAREKAR SHILPA SUDHAKAR (IN)
Application Number:
PCT/IN2001/000119
Publication Date:
May 30, 2002
Filing Date:
June 19, 2001
Export Citation:
Assignee:
DAFTARY GAUTAM (IN)
RIVANKAR SANGEETA HANURMESH (IN)
PAI SRIKANTH ANNAPPA (IN)
KOCHAREKAR SHILPA SUDHAKAR (IN)
RIVANKAR SANGEETA HANURMESH (IN)
PAI SRIKANTH ANNAPPA (IN)
KOCHAREKAR SHILPA SUDHAKAR (IN)
International Classes:
A61K9/107; A61K31/7048; A61K47/10; A61K47/20; A61K47/24; C07H17/08; A61K47/26; A61K47/44; A61P31/10; (IPC1-7): A61K9/107; A61K47/24; A61K47/26; A61K47/44; A61K31/7048
Foreign References:
| EP0202837A1 | 1986-11-26 | |||
| US5389373A | 1995-02-14 | |||
| EP0296845A1 | 1988-12-28 | |||
| US5364632A | 1994-11-15 |
Other References:
WALKER S ET AL: "Amphotericin B in lipid emulsion: Stability, compatibility and in vitro antifungal activity.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 42, no. 4, April 1998 (1998-04-01), pages 762 - 766, XP002189975, ISSN: 0066-4804
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