Title:
ANALYSIS METHOD AND ANALYSIS DEVICE
Document Type and Number:
WIPO Patent Application WO/2019/235011
Kind Code:
A1
Abstract:
This analysis method comprises: subjecting a sample to liquid chromatography; performing first mass spectrometry on the sample subjected to liquid chromatography to detect a first ion corresponding to cholesteryl ester and a second ion corresponding cholesteryl ester peroxide; and analyzing the degree of oxidation of the sample on the basis of the ratio of the intensity of the detected first ion and the intensity of the detected second ion.
Inventors:
YAMADA MASAKI (JP)
Application Number:
PCT/JP2019/009393
Publication Date:
December 12, 2019
Filing Date:
March 08, 2019
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62; G01N30/72; G01N30/86; G01N30/88
Domestic Patent References:
| WO2011007582A1 | 2011-01-20 | |||
| WO2004083869A1 | 2004-09-30 | |||
| WO2010047399A1 | 2010-04-29 |
Foreign References:
| JP2013076692A | 2013-04-25 | |||
| JP2017191056A | 2017-10-19 | |||
| US20160131618A1 | 2016-05-12 | |||
| JP2018109023A | 2018-07-12 |
Other References:
KAMLAGE B; MALDONADO S G; BETHAN B; PETER E; SCHMITZ O; LIEBENBERG V; SCHATZ P: "Quality Markers Addressing Preanalytical Variations of Blood and Plasma Processing Identified by Broad and Targeted Metabolite Profiling", CLINICAL CHEMISTRY, vol. 60, no. 2, 1 February 2014 (2014-02-01), pages 399 - 412, XP008172298, ISSN: 0009-9147, DOI: 10.1373/clinchem.2013.211979
SHU-PING HUI : "Analyses of Lipid Hydroperoxides and Physiologically Active Lipids by Mass Spectrometry", JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE, vol. 62, no. 3, 30 November 2013 (2013-11-30), pages 283 - 290, XP009525043, ISSN: 0047-1860
LAURA A. HEISKANENMATTI SUONIEMIHUNG XUAN TAKIRILL TARASOVKIM EKROOS: "Analytical Chemistry (USA", vol. 85, September 2013, ACS PUBLICATIONS, article "Long-Term Performance and Stability of Molecular Shotgun Lipidomic Analysis of Human Plasma Samples", pages: 8757 - 8763
BEATE KAMLAGESANDRA GONZALEZ MALDONADOBIANCA BETHANERIK PETEROLIVER SCHMITZVOLKER LIEBENBERGPHILIPP SCHATZ: "Clinical Chemistry (USA", vol. 60, February 2014, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, article "Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling", pages: 399 - 412
See also references of EP 3805750A4
SHU-PING HUI : "Analyses of Lipid Hydroperoxides and Physiologically Active Lipids by Mass Spectrometry", JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE, vol. 62, no. 3, 30 November 2013 (2013-11-30), pages 283 - 290, XP009525043, ISSN: 0047-1860
LAURA A. HEISKANENMATTI SUONIEMIHUNG XUAN TAKIRILL TARASOVKIM EKROOS: "Analytical Chemistry (USA", vol. 85, September 2013, ACS PUBLICATIONS, article "Long-Term Performance and Stability of Molecular Shotgun Lipidomic Analysis of Human Plasma Samples", pages: 8757 - 8763
BEATE KAMLAGESANDRA GONZALEZ MALDONADOBIANCA BETHANERIK PETEROLIVER SCHMITZVOLKER LIEBENBERGPHILIPP SCHATZ: "Clinical Chemistry (USA", vol. 60, February 2014, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, article "Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling", pages: 399 - 412
See also references of EP 3805750A4
Attorney, Agent or Firm:
NAGAI, Fuyuki et al. (JP)
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