Title:
ANTI-AGING MEDICINE D/S TARGETING AGING CELLS IN TISSUE MICROENVIRONMENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/032213
Kind Code:
A1
Abstract:
Provided in the present invention are an anti-aging medicine D/S having the effect of targeting aging cells in the tissue microenvironment and the use thereof. Dasatinib is used in combination with SRT2104, which has an extremely excellent effect on down-regulating or eliminating aging cells in the body, and thus the combination can be used for eliminating damaged cells in the tissue microenvironment such as damaged cells following chemotherapy or radiation therapy, and can also be used for eliminating natural aging cells that increase with age, thereby prolonging the survival period of an organism.
Inventors:
SUN YU (CN)
Application Number:
PCT/CN2020/110860
Publication Date:
February 25, 2021
Filing Date:
August 24, 2020
Export Citation:
Assignee:
SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K31/506; A61K31/5377; A61K45/00; A61P39/00
Foreign References:
| CN110934873A | 2020-03-31 | |||
| EP3643305A1 | 2020-04-29 | |||
| US20170216286A1 | 2017-08-03 | |||
| CN106163557A | 2016-11-23 | |||
| US20170216286A1 | 2017-08-03 | |||
| CN106943595A | 2017-07-14 |
Other References:
MINGXIAO FENG: "Role Of COX2 In Cellular Senescence", 1 January 2018 (2018-01-01), pages 1 - 130, XP055783643, Retrieved from the Internet
MICHAEL S BONKOWSKI; DAVID A SINCLAIR: "Slowing Ageing by Design: the Rise of NAD + And Sirtuin-activating Compounds", NAT REV MOL CELL BIOL, vol. 17, no. 11, 30 November 2016 (2016-11-30), pages 679 - 690, XP055321386, ISSN: 1471-0072, DOI: 10.1038/nrm.2016.93
YUJIRO KIDA , MICHAEL S.GOLIGORSKY: "Sirtuins, Cell Senescence, And Vascular Aging", CANADIAN JOURNAL OF CARDIOLOGY, vol. 32, no. 5, 1 May 2016 (2016-05-01), pages 634 - 641, XP055783649, ISSN: 0828-282X, DOI: 10.1016/j.cjca.2015.11.022
LEE CHANG , BAEK JUHWA, HAN SUN-YOUNG: "The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment", MOLECULES, vol. 22, no. 9, 1411, 25 August 2017 (2017-08-25), pages 1 - 14, XP055783650, DOI: https://www.mdpi.com/1420-3049/22/9/1411
KIRKLAND JAMES L., TCHKONIA TAMARA, ZHU YI, NIEDERNHOFER LAURA J., ROBBINS PAUL D: "The Clinical Potential of Senolytic Drugs", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, vol. 65, no. 10, 4 September 2017 (2017-09-04), pages 2297 - 2301, XP055783652, ISSN: 0002-8614, DOI: 10.1111/jgs.14969
MICHAEL S BONKOWSKI; DAVID A SINCLAIR: "Slowing Ageing by Design: the Rise of NAD + And Sirtuin-activating Compounds", NAT REV MOL CELL BIOL, vol. 17, no. 11, 30 November 2016 (2016-11-30), pages 679 - 690, XP055321386, ISSN: 1471-0072, DOI: 10.1038/nrm.2016.93
YUJIRO KIDA , MICHAEL S.GOLIGORSKY: "Sirtuins, Cell Senescence, And Vascular Aging", CANADIAN JOURNAL OF CARDIOLOGY, vol. 32, no. 5, 1 May 2016 (2016-05-01), pages 634 - 641, XP055783649, ISSN: 0828-282X, DOI: 10.1016/j.cjca.2015.11.022
LEE CHANG , BAEK JUHWA, HAN SUN-YOUNG: "The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment", MOLECULES, vol. 22, no. 9, 1411, 25 August 2017 (2017-08-25), pages 1 - 14, XP055783650, DOI: https://www.mdpi.com/1420-3049/22/9/1411
KIRKLAND JAMES L., TCHKONIA TAMARA, ZHU YI, NIEDERNHOFER LAURA J., ROBBINS PAUL D: "The Clinical Potential of Senolytic Drugs", JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, vol. 65, no. 10, 4 September 2017 (2017-09-04), pages 2297 - 2301, XP055783652, ISSN: 0002-8614, DOI: 10.1111/jgs.14969
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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