Title:
ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS
Document Type and Number:
WIPO Patent Application WO/2010/123599
Kind Code:
A3
Abstract:
This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as Staphylococcus aureus.
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Inventors:
OLDFIELD ERIC (US)
SONG YONGCHENG (US)
SONG YONGCHENG (US)
Application Number:
PCT/US2010/021800
Publication Date:
January 20, 2011
Filing Date:
January 22, 2010
Export Citation:
Assignee:
UNIV ILLINOIS (US)
OLDFIELD ERIC (US)
SONG YONGCHENG (US)
OLDFIELD ERIC (US)
SONG YONGCHENG (US)
International Classes:
C07C309/02; A61K31/215; A61K31/255; A61K31/662; C07C15/12; C07C15/14; C07C53/132; C07C59/01; C07C211/02; C07C229/06; C07C381/00; C07F9/40
Domestic Patent References:
| WO2005097100A2 | 2005-10-20 | |||
| WO2007133712A2 | 2007-11-22 |
Other References:
DATABASE WPI Derwent World Patents Index; AN 1998:724170
STOKES N.R. ET AL.: "Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening assay", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 48, 2005, pages 39709 - 39715
MAGNIN ET AL.: "1,1-Bisphosphonate Squalene Synthase.Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 14, 1995, pages 2596 - 2605
LAWRENCE R.L. ET AL.: "Enantioselective Synthesis of a-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral recognition in the Interactions of an a-Phosphono Sulfonate Inhibitor with Squalene Synthase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, no. 46, 1996, pages 11668 - 11669
SONG Y. ET AL.: "Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus: In Vitro, in Vivo, and Crystallographic Results", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, 2009, pages 3869 - 3880
SONG Y. ET AL.: "Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, 2009, pages 976 - 988
STOKES N.R. ET AL.: "Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening assay", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 48, 2005, pages 39709 - 39715
MAGNIN ET AL.: "1,1-Bisphosphonate Squalene Synthase.Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 14, 1995, pages 2596 - 2605
LAWRENCE R.L. ET AL.: "Enantioselective Synthesis of a-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral recognition in the Interactions of an a-Phosphono Sulfonate Inhibitor with Squalene Synthase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, no. 46, 1996, pages 11668 - 11669
SONG Y. ET AL.: "Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus: In Vitro, in Vivo, and Crystallographic Results", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, 2009, pages 3869 - 3880
SONG Y. ET AL.: "Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, 2009, pages 976 - 988
Attorney, Agent or Firm:
PENNER, Steven J. et al. (Winner and Sullivan P.C.,4875 Pearl East Circle,Suite 20, Boulder Colorado, US)
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