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Patent Searching and Data


Title:
ANTI-CANCER DRUG AND TREATMENT METHOD FOR TREATING TUMORS HAVING MULTIDRUG RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2014/073740
Kind Code:
A1
Abstract:
The present invention provides an anti-tumor drug comprising, as active ingredients, Wip1 inhibitors and Mdm-2/p53 interaction inhibitors so as to effectively treat malignant tumors.

Inventors:
CHO KWANG HYUN (KR)
CHOI MIN SOO (KR)
JUE SHI (CN)
Application Number:
PCT/KR2012/010659
Publication Date:
May 15, 2014
Filing Date:
December 07, 2012
Export Citation:
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Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K31/7105; A61K31/7088; A61P35/00
Foreign References:
US7834016B22010-11-16
Other References:
BUSS, M. C. ET AL.: "HDM2 promotes WIP1-mediated medulloblastoma growth", NEURO-ONCOLOGY, vol. 14, no. 4, 29 February 2012 (2012-02-29), pages 440 - 458
SPINNLER, C. ET AL.: "Abrogation of Wipl expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX", CELL DEATH AND DIFFERENTIATION, vol. 18, 2011, pages 1736 - 1745
ZHANG, X. ET AL.: "Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response", CANCER RES., vol. 69, no. 20, 2009, pages 7960 - 7968
LU, X. ET AL.: "The Wipl phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop", CANCER CELL, vol. 12, 2007, pages 342 - 354
Attorney, Agent or Firm:
HAN, Yun-Ho et al. (KR)
한윤호 (KR)
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