Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANTI-CCR8 ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/142002
Kind Code:
A1
Abstract:
The present disclosure is directed to antibodies or antigen-binding portions thereof that specifically bind human CCR8, polynucleotides and vectors encoding the same, and pharmaceutical compositions comprising the same. Some aspects of the disclosure are directed to methods of treating a disease or condition comprising administering the anti-CCR8 antibody to a subject in need thereof.

Inventors:
HOLLAND PAMELA M (US)
LAKE ANDREW (US)
DULAK AUSTIN (US)
SMITH ERNEST (US)
SCRIVENS MARIA (US)
HARVEY CARRIE (US)
KIRK RENEE (US)
BALCH LESLIE (US)
DAS SONIA G (US)
WELLS CHRISTOPHER CONVERSE (US)
Application Number:
PCT/US2021/012329
Publication Date:
July 15, 2021
Filing Date:
January 06, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
VACCINEX INC (US)
International Classes:
A61K39/395; A61P35/00; C07K16/28
Domestic Patent References:
WO2007044756A22007-04-19
WO2018112032A12018-06-21
WO1994004678A11994-03-03
WO1994025591A11994-11-10
WO1996027011A11996-09-06
WO2008024188A22008-02-28
WO2007024715A22007-03-01
WO2015103072A12015-07-09
WO1999051642A11999-10-14
WO1994029351A21994-12-22
WO2006029879A22006-03-23
WO2005100402A12005-10-27
WO2004056312A22004-07-08
WO1990002809A11990-03-22
WO1991010737A11991-07-25
WO1992001047A11992-01-23
WO1992018619A11992-10-29
WO1993011236A11993-06-10
WO1995015982A21995-06-15
WO1995020401A11995-08-03
Foreign References:
EP3431105A12019-01-23
US6005079A1999-12-21
US4676980A1987-06-30
US6194551B12001-02-27
US5648260A1997-07-15
US5624821A1997-04-29
US5500362A1996-03-19
US6737056B12004-05-18
US7332581B22008-02-19
US20050014934A12005-01-20
US7371826B22008-05-13
US1994001875W
US9300829W1993-02-05
US3773919A1973-11-20
EP0058481A11982-08-25
EP0133988A21985-03-13
EP0036676A11981-09-30
EP0088046A21983-09-07
EP0143949A11985-06-12
US6300064B12001-10-09
US5698426A1997-12-16
US5223409A1993-06-29
US5403484A1995-04-04
US5580717A1996-12-03
US5427908A1995-06-27
US5750753A1998-05-12
US5821047A1998-10-13
US5571698A1996-11-05
US5516637A1996-05-14
US5780225A1998-07-14
US5658727A1997-08-19
US5733743A1998-03-31
US5969108A1999-10-19
US6995259B12006-02-07
US6001329A1999-12-14
US6933368B22005-08-23
Other References:
DANIEL O. VILLARREAL ET AL: "Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer", CANCER RESEARCH, vol. 78, no. 18, 15 September 2018 (2018-09-15), US, pages 5340 - 5348, XP055631142, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-1119
D. B. HOELZINGER ET AL: "Blockade of CCL1 Inhibits T Regulatory Cell Suppressive Function Enhancing Tumor Immunity without Affecting T Effector Responses", THE JOURNAL OF IMMUNOLOGY, vol. 184, no. 12, 7 May 2010 (2010-05-07), US, pages 6833 - 6842, XP055306968, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0904084
YEUNG ET AL., BIOTECHNOL PROG, vol. 18, 2002, pages 212 - 220
HUDSONKORTT, J. IMMUNOL. METHODS, vol. 231, no. 1, 1999, pages 177 - 189
NUTTALL ET AL., CURR. PHARM. BIOTECH., vol. 1, 2000, pages 253 - 263
TODOROVSKA ET AL., J. IMMUNOL. METHODS, vol. 248, no. 1, 2001, pages 47 - 66
POLJAK, STRUCTURE, vol. 2, no. 12, 1994, pages 1121 - 1123
RONDONMARASCO, ANNU. REV. MICROBIOL., vol. 51, 1997, pages 257 - 283
MUYLDERMANS ET AL., TRENDS BIOCHEM. SCI., vol. 26, 2001, pages 230 - 235
REICHMANN ET AL., J. IMMUNOL. METH., vol. 231, 1999, pages 25 - 38
SONGSIVILAILACHMANN, CLIN. EXP. IMMUNOL., vol. 79, 1990, pages 315 - 321
KOSTELNY ET AL., J. IMMUNOL., vol. 148, no. 5, 1992, pages 1547 - 1553
MILSTEINCUELLO, NATURE, vol. 305, 1983, pages 537 - 539
SURESH ET AL., METHODS ENZYMOL, vol. 121, 1986, pages 210
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81
SHALABY ET AL., J. EXP. MED., vol. 175, 1992, pages 217 - 225
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
GRUBER ET AL., J. IMMUNOL., vol. 152, 1994, pages 5368
TUTT ET AL., J. IMMUNOL., vol. 147, 1991, pages 60
KOSTELNY ET AL., J IMMUNOL, vol. 148, no. 5, 1992, pages 1547 - 1553
HOLLINGER ET AL., PROC NATL ACAD SCI USA, vol. 90, 1993, pages 6444 - 6448
GRUBER ET AL., J IMMUNOL, vol. 152, 1994, pages 5368
ZAPATA ET AL., PROTEIN ENG, vol. 8, no. 10, 1995, pages 1057 - 1062
TUTT ET AL., J IMMUNOL, vol. 147, 1991, pages 60
HANES ET AL., NAT BIOTECHNOL, vol. 18, no. 11, 2000, pages 1287 - 1292
BARSHESHET ET AL., PNAS, vol. 114, no. 23, 6 June 2017 (2017-06-06), pages 6086 - 91
"UniProt", Database accession no. P51685
GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, vol. 202, 1996, pages 163
STAHLI ET AL., METHODS IN ENZYMOLOGY, vol. 9, 1983, pages 242
KIRKLAND ET AL., J. IMMUNOL., vol. 137, 1986, pages 3614
MOREL ET AL., MOL. IMMUNOL., vol. 25, no. 1, 1988, pages 7
CHEUNG ET AL., VIROLOGY, vol. 176, 1990, pages 546
MOLDENHAUER ET AL., SCAND. J. IMMUNOL., vol. 32, 1990, pages 77
LONBERG ET AL., NATURE, vol. 368, no. 6474, 1994, pages 856 - 859
KETTLEBOROUGH ET AL., EUR J IMMUNOL, vol. 113, 1994, pages 952 - 958
LONBERGHUSZAR, INTERN. REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
HARDINGLONBERG, ANN. N.Y. ACAD. SCI., vol. 764, 1995, pages 536 - 546
BATZER ET AL., NUCLEIC ACID RES, vol. 19, 1991, pages 5081
OHTSUKA ET AL., BIOL. CHEM., vol. 260, 1985, pages 2605 - 2608
CASSOLROSSOLINI ET AL., MOL. CELL. PROBES, vol. 8, 1992, pages 91 - 98
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
PEARSONLIPMAN, PROC. NAT'L. ACAD. SCI. USA, vol. 85, 1988, pages 2444
"Wisconsin Genetics Software Package", GENETICS COMPUTER GROUP, article "GAP, BESTFIT, FASTA, and TFASTA"
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
BERGE ET AL., JPHARM SCI, vol. 66, 1977, pages 1 - 19
LONBERG, NATURE BIOTECH, vol. 23, no. 9, 2005, pages 1117 - 1125
E. MEYERSW. MILLER, CABIOS, vol. 4, 1989, pages 11 - 17
ALTSCHUL ET AL., NUCLEIC ACIDS RES, vol. 25, no. 17, 1997, pages 3389 - 3402
BRUGGEMANN, M. ET AL., J. EXP. MED., vol. 166, 1987, pages 1351 - 1361
JOJUNG, EXPERIMENTAL & MOLECULAR MEDICINE, vol. 48, 2016, pages e207
BURTON ET AL., ADVIMMUN, vol. 51, 1992, pages 1 - 18
CANFIELD ET AL., J EXP MED, vol. 173, 1991, pages 1483 - 1491
MUELLER ET AL., MOL IMMUNOL, vol. 34, no. 6, 1997, pages 441 - 452
CARON ET AL., J EXP MED, vol. 176, 1992, pages 1191 - 1195
SHOPES, IMMUNOL, vol. 148, 1992, pages 2918 - 2922
DUNCANWINTER, NATURE, vol. 322, 1988, pages 738 - 40
RAVETCHKINET, ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
HELLSTROM, I. ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 83, 1986, pages 7059 - 7063
HELLSTROM, I ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 82, 1985, pages 1499 - 1502
CLYNES ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 95, 1998, pages 652 - 656
CRAGG, M.S. ET AL., BLOOD, vol. 101, 2003, pages 1045 - 1052
CRAGG, M.S.M.J. GLENNIE, BLOOD, vol. 103, 2004, pages 2738 - 2743
PETKOVA, S.B. ET AL., INT'L. IMMUNOL., vol. 18, no. 12, 2006, pages 1759 - 1769
SHIELDS ET AL., J. BIOL. CHEM., vol. 9, no. 2, 2001, pages 6591 - 6604
IDUSOGIE ET AL., J. IMMUNOL., vol. 164, 2000, pages 4178 - 4184
GUYER ET AL., J. IMMUNOL., vol. 117, 1976, pages 587
WRIGHT ET AL., EMBO J, vol. 10, no. 10, 1991, pages 2717 - 2723
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
MCCAFFERTY ET AL., NATURE, vol. 348, 1990, pages 552 - 554
HUANGKAMIHIRA, BIOTECHNOL. ADV., vol. 31, no. 2, pages 208 - 23
GUPTA ET AL., VACCINE, vol. 13, no. 14, 1995, pages 1263 - 1276
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
EPPSTEIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 3688 - 3692
BIEG ET AL., AUTOIMMUNITY, vol. 31, no. 1, 1999, pages 15 - 24
LODMELL ET AL., VACCINE, vol. 18, 2000, pages 1059 - 1066
JOHNSON ET AL., J MED CHEM, vol. 42, 1999, pages 4640 - 4649
BALDRIDGE ET AL., METHODS, vol. 19, 1999, pages 103 - 107
SCHOONBROODT ET AL., NUCLEIC ACIDS RES, vol. 33, no. 9, 2005, pages e81
ETZ ET AL., JBACTERIOL, vol. 183, 2001, pages 6924 - 6935
CORNELIS, CURR OPIN BIOTECHNOL, vol. 11, 2000, pages 450 - 454
KLEMM ET AL., MICROBIOLOGY, vol. 146, 2000, pages 3025 - 3032
KIEKE ET AL., PROTEIN ENG, vol. 10, 1997, pages 1303 - 1310
BODER ET AL., METHODS ENZYMOLOGY, vol. 328, 2000, pages 430 - 444
GRABHERR ET AL., COMB CHEM HIGH THROUGHPUT SCREEN, vol. 4, 2001, pages 185 - 192
MICHAEL ET AL., GENE THER, vol. 2, 1995, pages 660 - 668
PEREBOEV ET AL., J VIROL, vol. 75, 2001, pages 7107 - 7113
SCHAFFITZEL ET AL., J IMMUNOL METHODS, vol. 231, no. 1-2, 1999, pages 147 - 157
SHI ET AL., JMB, vol. 397, 2010, pages 385 - 396
BRINKMAN ET AL., J IMMUNOL METHODS, vol. 184, 1995, pages 177 - 186
PERSIC ET AL., GENE, vol. 187, 1997, pages 9 - 18
BURTON ET AL., ADVANCES IN IMMUNOLOGY, vol. 57, 1994, pages 191 - 280
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
MERZ ET AL., J NEUROSCI METHODS, vol. 62, no. 1-2, 1995, pages 213 - 9
DI NIRO ET AL.: "388", BIOCHEM J, 2005, pages 889 - 894
ENGBERG ET AL., METHODS MOL BIOL, vol. 51, 1995, pages 355 - 376
HOOGENBOOM, TRENDS IN BIOTECHNOLOGY, vol. 15, 1997, pages 62 - 70
CHASTEEN ET AL., NUCLEIC ACIDS RES, vol. 34, no. 21, 2006, pages e145
SHIRAISHI ET AL., NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 51, no. 1, 2007, pages 129 - 130
MULLIGANBERG, PROC NATL ACAD SCI USA, vol. 78, 1981, pages 2072
SOUTHERNBERG, MOLAPPL GENET, vol. 1, 1982, pages 327
WIGLER ET AL., CELL, vol. 16, 1979, pages 77
SARVER ET AL., PROC NATL ACAD SCI USA, vol. 79, 1982, pages 7147
DEANS ET AL., PROC NATL ACAD SCI USA, vol. 81, 1984, pages 1292
LUSKYBOTCHAN, NATURE, vol. 293, pages 79
HOUDEBINE, CURR OPIN BIOTECHNOL, vol. 13, no. 6, 2002, pages 625 - 629
VAN KUIK-ROMEIJN ET AL., TRANSGENIC RES, vol. 9, no. 2, 2000, pages 155 - 159
HOU ET AL., CYTOKINE, vol. 10, 1998, pages 319 - 30
"Current Protocols in Molecular Biology", 2001, COLD SPRING HARBOR LABORATORY PRESS
KASZUBSKA ET AL., PROTEIN EXPRESSION AND PURIFICATION, vol. 18, 2000, pages 213 - 220
SCOPES: "Protein Purification", 1994, SPRINGER-VERLAG
ROGERS ET AL., J NUCL MED, vol. 38, 1997, pages 1221 - 1229
WELCHREDVANLY: "Handbook of Radiopharmaceuticals: Radiochemistry and Applications", 2003, JOHN WILEY AND SONS
LEE ET AL., BIOCONJUG CHEM, vol. 10, no. 6, 1999, pages 973 - 8
KINSTLER ET AL., ADVANCED DRUG DELIVERIES REVIEWS, vol. 54, 2002, pages 477 - 485
ROBERTS ET AL., ADVANCED DRUG DELIVERY REVIEWS, vol. 54, 2002, pages 459 - 476
PAVISIC ET AL., INT J PHARM, vol. 387, no. 1-2, 2010, pages 110 - 119
CO ET AL., MOL IMMUNOL, vol. 30, 1993, pages 1361
Attorney, Agent or Firm:
KIM, Ji Eun et al. (US)
Download PDF: