Title:
ANTI-HER-2 ANTIBODY-GRANULOCYTE REGULATORY FACTOR FUSION PROTEIN, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011662
Kind Code:
A1
Abstract:
Provided are an anti-Her-2 antibody-granulocyte regulatory factor fusion protein, a preparation method therefor and an application thereof. Specifically, this relates to a fusion protein, a single chain of the fusion protein comprising the following elements fused together: (a) a first protein element; (b) a second protein element; and (c) optionally, a joint element located between the first protein element and the second protein element. The first protein element is an antigen recognition module, for example, a protein element of an anti-Her-2 antibody or an active fragment thereof; the second protein element is a granulocyte colony stimulating factor. The present fusion protein has advantages in precise recognition, immunotherapy, controllable toxicity, and enhanced ADCC, and also has the synergistic effect of high-efficiency tumor cell killing activity, as well as low toxicity and side effects.
Inventors:
CHEN YI (CN)
CAI ZELING (CN)
LI PENG (CN)
ZHANG RONGHUI (CN)
SONG YAQIN (CN)
ZHANG LIQIANG (CN)
CAI ZELING (CN)
LI PENG (CN)
ZHANG RONGHUI (CN)
SONG YAQIN (CN)
ZHANG LIQIANG (CN)
Application Number:
PCT/CN2022/110926
Publication Date:
February 09, 2023
Filing Date:
August 08, 2022
Export Citation:
Assignee:
SHANGHAI CELGEN BIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K19/00; A61K38/19; A61K47/65; A61K47/68; A61P35/00; C12N15/62
Foreign References:
| US20030187225A1 | 2003-10-02 | |||
| CN103755812A | 2014-04-30 | |||
| CN1410450A | 2003-04-16 | |||
| CN1311332A | 2001-09-05 |
Other References:
CRUZ, J. S. D. ET AL.: "Anti-HER2/neu IgG3–(IL-2) and anti-HER2/neu IgG3–(GM-CSF) promote HER2/neu processing and presentation by dendritic cells: Implications in immunotherapy and vaccination strategies", MOLECULAR IMMUNOLOGY, vol. 43, 23 May 2005 (2005-05-23), pages 667 - 676, XP025037173, DOI: 10.1016/j.molimm.2005.04.007
FANG YONGXIANG, FENG HAIYAN, MOSCOW, JING ZHIZHONG: "Cytokine Fusion Protein Technology and Its Application Prospects", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, FOURTH MILITARY MEDICAL UNIVERSITY, XI'AN, CN, vol. 25, no. 9, 31 December 2009 (2009-12-31), CN , pages 856 - 859, XP093031509, ISSN: 1007-8738, DOI: 10.13423/j.cnki.cjcmi.005177856
GUO XIN: " Protective Immune Response against HER2/neu Expressing Tumors Induced by Inoculation of Novel Anti-HER2/neu Cytokine Fusion Proteins with Soluble Protein Antigen Conjugates", INTERNATIONAL JOURNAL OF BIOLOGICALS, vol. 29, no. 6, 31 December 2006 (2006-12-31), pages 279 - 279, XP093031514
FANG YONGXIANG, FENG HAIYAN, MOSCOW, JING ZHIZHONG: "Cytokine Fusion Protein Technology and Its Application Prospects", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, FOURTH MILITARY MEDICAL UNIVERSITY, XI'AN, CN, vol. 25, no. 9, 31 December 2009 (2009-12-31), CN , pages 856 - 859, XP093031509, ISSN: 1007-8738, DOI: 10.13423/j.cnki.cjcmi.005177856
GUO XIN: " Protective Immune Response against HER2/neu Expressing Tumors Induced by Inoculation of Novel Anti-HER2/neu Cytokine Fusion Proteins with Soluble Protein Antigen Conjugates", INTERNATIONAL JOURNAL OF BIOLOGICALS, vol. 29, no. 6, 31 December 2006 (2006-12-31), pages 279 - 279, XP093031514
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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