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Title:
ANTI-HER2 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2020/196475
Kind Code:
A1
Abstract:
A novel anti-HER2 antibody-pyrrolobenzodiazepine (PBD) derivative conjugate; a medicine using the antibody-drug conjugate that has a therapeutic effect on a tumor; and a method for treating a tumor using the antibody-drug conjugate or the medicine.

Inventors:
HARADA NAOYA (JP)
YONEDA KOZO (JP)
HAYAKAWA ICHIRO (JP)
Application Number:
PCT/JP2020/012885
Publication Date:
October 01, 2020
Filing Date:
March 24, 2020
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Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K39/395; A61K31/4192; A61K31/551; A61K45/00; A61K47/68; A61P35/00; C07K1/22; C07K7/06; C07K7/08; C07K16/28; C07K16/46; C12N5/10; C12N15/13; C12N15/63; C12P21/08
Domestic Patent References:
WO2012075581A12012-06-14
WO2011084496A12011-07-14
WO2017137556A12017-08-17
WO2019065964A12019-04-04
Foreign References:
JP2015534996A2015-12-07
US20090149449A12009-06-11
JP2017526614A2017-09-14
Other References:
TSUCHIKAMA, KYOJI ET AL.: "Antibody-drug conjugates: recent advances in conjugation and linker chemistries", PROTEIN& CELL, vol. 9, no. 1, 2018, pages 33 - 46, XP055461467, ISSN: 1674-800X, DOI: 10.1007/s13238-016-0323-0
Attorney, Agent or Firm:
KAWAGUTI & PARTNERS (JP)
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