Title:
ANTI-HUMAN MEMBRANE-TYPE ADAM28 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2016/143702
Kind Code:
A1
Abstract:
The present invention provides an antibody which has an activity of binding specifically to human membrane-type ADAM28 at an epitope present in a domain lying between amino acid residue 524 and amino acid residue 659 in the amino acid sequence represented by SEQ ID NO: 2. The present invention also provides a drug delivery medium for delivering a drug to a cell or tissue in which human membrane-type ADAM28 can be expressed, said drug delivery medium comprising the antibody.
Inventors:
MIYAKOSHI AKIRA (JP)
KOJOH KANEHISA (JP)
MOCHIZUKI SATSUKI (JP)
SHIMODA MASAYUKI (JP)
OKADA YASUNORI (JP)
KOJOH KANEHISA (JP)
MOCHIZUKI SATSUKI (JP)
SHIMODA MASAYUKI (JP)
OKADA YASUNORI (JP)
Application Number:
PCT/JP2016/056810
Publication Date:
September 15, 2016
Filing Date:
March 04, 2016
Export Citation:
Assignee:
GENEFRONTIER CORP (JP)
UNIV KEIO (JP)
UNIV KEIO (JP)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C07K16/30; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| WO2014073292A1 | 2014-05-15 |
Other References:
YASUNORI OKADA ET AL.: "MMP to ADAM ni yoru Gan Soshikinai Bisho Kankyo Inshi Taisha ? Kaishita Gan Saibo no Zoshoku.ShitsujunvTen'i: ADAM28 no Idenshi Hatsugen to Hitogata Ko-ADAM28 Kotai no Kaihatsu to Gan Saibo Zoshoku.Ten'i Yokusei", MINISTRY OF HEALTH, LABOUR AND WELFARE KAGAKU KENKYUHI HOJOKIN DAI 3 JI TAI GAN SOGO SENRYAKU KENKYU JIGYO, SHITSUJUN.TEN'I TO, GAN NO JUYONA RINSHOTEKI TOKUSEI NO BYORI.BYOTAIGAKU BUNSHI KIBAN NO KAISEKI TO SORE NI MOTOZUKU SHINDAN. CHIRYOHO NO KAIH, 2014, pages 9 - 12, XP009506061
BRIDGES L. C. ET AL.: "Integrin alpha4beta1-Dependent Adhesion to ADAM 28 (MDC-L) Requires an Extended Surface of the Disintegurin Domain", BIOCHEMISTRY, vol. 42, 2003, pages 3734 - 3741, XP002511877
BRIDGES L. C. ET AL.: "The Lymphocyte Metalloprotease MDC-L (ADAM 28) Is a Ligand for the Integrin alpha4beta1", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 5, 2002, pages 3784 - 3792, XP055309822
MITSUI Y. ET AL.: "ADAM28 Is Overexpressed in Human Breast Carcinomas: Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3", CANCER RESEARCH, vol. 66, no. 20, 2006, pages 9913 - 9920, XP055255298
OHTSUKA T. ET AL.: "ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis", INTERNATIONAL JOURNAL OF CANCER, vol. 118, 2006, pages 263 - 273, XP055009343
See also references of EP 3266799A4
BRIDGES L. C. ET AL.: "Integrin alpha4beta1-Dependent Adhesion to ADAM 28 (MDC-L) Requires an Extended Surface of the Disintegurin Domain", BIOCHEMISTRY, vol. 42, 2003, pages 3734 - 3741, XP002511877
BRIDGES L. C. ET AL.: "The Lymphocyte Metalloprotease MDC-L (ADAM 28) Is a Ligand for the Integrin alpha4beta1", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 5, 2002, pages 3784 - 3792, XP055309822
MITSUI Y. ET AL.: "ADAM28 Is Overexpressed in Human Breast Carcinomas: Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3", CANCER RESEARCH, vol. 66, no. 20, 2006, pages 9913 - 9920, XP055255298
OHTSUKA T. ET AL.: "ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis", INTERNATIONAL JOURNAL OF CANCER, vol. 118, 2006, pages 263 - 273, XP055009343
See also references of EP 3266799A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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