ANTI-INFLAMATORY MACROLIDE CONJUGATES

WIPO Patent Application WO2006075255

A3

The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a dibenzo[e,/z]azulene subunit with anti-inflammatory, analgesic and/or antipyretic activity and L represents a linking group covalently linking M and D; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals.

MERCEP MLADEN (HR)
MESIC MILAN (HR)
MARKOVIC STRIBOR (HR)
PESIC DIJANA (HR)
OZIMEC LANDEK IVANA (HR)
KOMAC MARIJANA (HR)
MAKARUHA STEGIC ORESTA (HR)
SELMANI SELVIRA (HR)
TOMASKOVIC LINDA (HR)
BANJANAC MIHAILO (HR)

PCT/IB2006/001079

October 26, 2006

January 13, 2006

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GLAXOSMITHKLINE ZAGREB (HR)
MERCEP MLADEN (HR)
MESIC MILAN (HR)
MARKOVIC STRIBOR (HR)
PESIC DIJANA (HR)
OZIMEC LANDEK IVANA (HR)
KOMAC MARIJANA (HR)
MAKARUHA STEGIC ORESTA (HR)
SELMANI SELVIRA (HR)
TOMASKOVIC LINDA (HR)
BANJANAC MIHAILO (HR)

C07D495/04; A61K31/55; A61K31/7048; A61K31/7052; A61P29/00; C07D498/04; C07H17/08

WO2004005309A2	2004-01-15
WO2004078763A1	2004-09-16
WO2003097649A2	2003-11-27
WO2001087890A1	2001-11-22
WO2003084964A1	2003-10-16
WO2003099823A2	2003-12-04
WO2003099827A1	2003-12-04
WO2003097648A1	2003-11-27

US3711489A

1973-01-16

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