Title:
ANTI-TUMOR EFFECTIVE COMPONENT OF HEDYOTIS DIFFUSA, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/196105
Kind Code:
A1
Abstract:
The present invention relates to the field of medicines, in particular to an anti-tumor effective component of Hedyotis diffusa, a preparation method therefor and the use thereof. Provided in the present invention is the use of one or a combination of kaempferol-3-O-[2-O-(6-O-E-feruloyl)-β-D-glucopyranose]-β-D-pyranose and E-6-O-p-coumaroylpaederoside methyl ester in tumor resistance or the preparation of an anti-tumor drug. The research of the present invention has shown that both a kaempferol-3-O-[2-O-(6-O-E-feruloyl)-β-D-glucopyranose]-β-D-pyranose compound monomer and an E-6-O-p-coumaroylpaederoside methyl ester compound monomer have very strong anti-tumor activity. In the in-vivo anti-tumor activity research, the inhibition rates thereof can reach 48.97% and 45.96%, respectively; and when both are combined to inhibit tumor cells, the research reveals that the two monomers have an obvious effect of synergistically inhibiting tumors.
Inventors:
WANG YINGFENG (CN)
HONG YA (CN)
HONG YA (CN)
Application Number:
PCT/CN2020/082880
Publication Date:
October 07, 2021
Filing Date:
April 02, 2020
Export Citation:
Assignee:
GUANGDONG NEW EAR LIFE TECH CO LTD (CN)
International Classes:
A61K31/7048; A61P35/00; C07H1/08; C07H19/01
Domestic Patent References:
| WO2008038849A1 | 2008-04-03 |
Foreign References:
| CN101096378A | 2008-01-02 | |||
| CN102218097A | 2011-10-19 | |||
| CN108888674A | 2018-11-27 |
Other References:
LI FANGLI: "Studies on the Chemical Constituents of Hedyotis Diffusa Willd. and Its Anti-tumour Activity in Vitro", CHINESE MASTER’S THESES FULL-TEXT DATABASE, MEDICINE & HEALTH SCIENCES, 15 March 2017 (2017-03-15), XP055854419
LI ZHONGFENG ．, QIU XIAOZHEN;WANG YU;LIU XINFENG;KONG LINGSHUANG;WANG YINGFENG: "Isolation and Purification Process of the Monomers in Hedyotis Diffusa Effective Parts with Dynamic NMR Spectroscopy Methods", [SHOUDU-SHIFAN-DAXUE-XUEBAO / ZIRAN-KEXUE-BAN] SHOUDU-SHIFAN-DAXUE-XUEBAO = JOURNAL OF CAPITAL NORMAL UNIVERSITY, SHOUDU-SHIFAN-DAXUE, CN, vol. 35, no. 5, 31 October 2014 (2014-10-31), CN, pages 37 - 42, XP055854417, ISSN: 1004-9398, DOI: 10.19789/j.1004-9398.2014.05.009
LI, M. ; JIANG, R.W. ; HON, P.M. ; CHENG, L. ; LI, L.L. ; ZHOU, J.R. ; SHAW, P.C. ; BUT, P.P.H.: "Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 119, no. 3, 1 April 2010 (2010-04-01), NL, pages 1239 - 1245, XP026754911, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2009.09.013
ZHANG LIN; ZHANG JING; QI BING; JIANG GUOQIANG; LIU JIA; ZHANG PEI; MA YUAN; LI WEILING: "The anti-tumor effect and bioactive phytochemicals ofHedyotis diffusawilld on ovarian cancer cells", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 192, 15 July 2016 (2016-07-15), IE, pages 132 - 139, XP029763305, ISSN: 0378-8741, DOI: 10.1016/j.jep.2016.07.027
YINGFENG WANG, YI ZHENG, BAOSHAN KU, HAIYAN YAO, GUANGYIN YAO, YANGLI WAN: "Anti-tumor Activity of Hedyotis Diffusa Willd. in Mice", JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES, vol. 22, no. 3, 31 December 2013 (2013-12-31), pages 272 - 276, XP009531098, ISSN: 1003-1057, DOI: 10.5246/jcps.2013.02.039
LI ZHONGFENG ．, QIU XIAOZHEN;WANG YU;LIU XINFENG;KONG LINGSHUANG;WANG YINGFENG: "Isolation and Purification Process of the Monomers in Hedyotis Diffusa Effective Parts with Dynamic NMR Spectroscopy Methods", [SHOUDU-SHIFAN-DAXUE-XUEBAO / ZIRAN-KEXUE-BAN] SHOUDU-SHIFAN-DAXUE-XUEBAO = JOURNAL OF CAPITAL NORMAL UNIVERSITY, SHOUDU-SHIFAN-DAXUE, CN, vol. 35, no. 5, 31 October 2014 (2014-10-31), CN, pages 37 - 42, XP055854417, ISSN: 1004-9398, DOI: 10.19789/j.1004-9398.2014.05.009
LI, M. ; JIANG, R.W. ; HON, P.M. ; CHENG, L. ; LI, L.L. ; ZHOU, J.R. ; SHAW, P.C. ; BUT, P.P.H.: "Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 119, no. 3, 1 April 2010 (2010-04-01), NL, pages 1239 - 1245, XP026754911, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2009.09.013
ZHANG LIN; ZHANG JING; QI BING; JIANG GUOQIANG; LIU JIA; ZHANG PEI; MA YUAN; LI WEILING: "The anti-tumor effect and bioactive phytochemicals ofHedyotis diffusawilld on ovarian cancer cells", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 192, 15 July 2016 (2016-07-15), IE, pages 132 - 139, XP029763305, ISSN: 0378-8741, DOI: 10.1016/j.jep.2016.07.027
YINGFENG WANG, YI ZHENG, BAOSHAN KU, HAIYAN YAO, GUANGYIN YAO, YANGLI WAN: "Anti-tumor Activity of Hedyotis Diffusa Willd. in Mice", JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES, vol. 22, no. 3, 31 December 2013 (2013-12-31), pages 272 - 276, XP009531098, ISSN: 1003-1057, DOI: 10.5246/jcps.2013.02.039
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
Download PDF: