Title:
ANTI-TUMOR PHARMACEUTICAL COMBINATION
Document Type and Number:
WIPO Patent Application WO/2022/166990
Kind Code:
A1
Abstract:
Provided in the present invention are a 2-(substituted phenoxy)aromatic formic acid FTO inhibitor, a preparation method therefor and the use thereof, and specifically disclosed are a compound represented by formula (I), and the use of a pharmaceutically acceptable salt, a hydrate, a solvate, or a prodrug thereof. The compound can be used in combination with an immune checkpoint inhibitor for treating solid tumors, such as melanoma, lung cancer, colon cancer, renal cancer, pancreatic cancer, lung cancer and osteosarcoma.
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Inventors:
YANG CAIGUANG (CN)
DONG ZE (CN)
XU HONGJIAO (CN)
WANG CHUANHUI (CN)
HUANG YUE (CN)
DONG ZE (CN)
XU HONGJIAO (CN)
WANG CHUANHUI (CN)
HUANG YUE (CN)
Application Number:
PCT/CN2022/075561
Publication Date:
August 11, 2022
Filing Date:
February 08, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D231/12; A61K31/41; A61K31/415; A61K31/4192; A61K31/42; A61K31/4409; A61K31/5375; A61P35/00; C07D213/24; C07D249/06; C07D257/04; C07D261/08; C07D265/30
Domestic Patent References:
| WO2018157843A1 | 2018-09-07 | |||
| WO2019204257A1 | 2019-10-24 | |||
| WO2000041505A2 | 2000-07-20 |
Foreign References:
| CN104069092A | 2014-10-01 | |||
| CN102348689A | 2012-02-08 |
Other References:
HUANG YUE, ET AL: "Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia", CANCER CELL, CELL PRESS, US, vol. 35, no. 4, 1 April 2019 (2019-04-01), US , pages 677 - 691.e10, XP055957252, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2019.03.006
WWW, ET AL: "Chemical Science A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6 -methyladenosine demethylase FTO", CHEMICAL SCIENCE, 1 January 2015 (2015-01-01), pages 112 - 122, XP055957255, Retrieved from the Internet [retrieved on 20220902]
WWW, ET AL: "Chemical Science A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6 -methyladenosine demethylase FTO", CHEMICAL SCIENCE, 1 January 2015 (2015-01-01), pages 112 - 122, XP055957255, Retrieved from the Internet
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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