Title:
ANTI-TUMOR PHARMACEUTICAL COMPOSITION AND METHOD FOR INCREASING SOLUBILITY OF COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/136089
Kind Code:
A1
Abstract:
A quinoline anti-tumor pharmaceutical composition containing a phosphorus substituent and a method for increasing the solubility of a pharmaceutical active ingredient in said pharmaceutical composition, the pharmaceutical composition comprising a pharmaceutical active ingredient and a pharmaceutically acceptable acid. By adding an acid compound to a pharmaceutical active ingredient, acid may be released after a drug has entered the gastric juice, thereby increasing the acidity of the gastric juice and lowering the pH value of the gastric juice. The decrease in the pH value of the gastric juice provides a favorable environment for the dissolution of the drug, thus facilitating the dissolution and absorption of the pharmaceutical active ingredient within the stomach, and improving the bioavailability of the drug within the body. Also provided is a method for increasing the solubility in water of a quinoline anti-tumor drug containing a phosphorus substituent.
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Inventors:
LU NING (CN)
CHENG ZHIHUI (CN)
YANG HONGZHEN (CN)
HU HUAIZHONG (CN)
CHENG ZHIHUI (CN)
YANG HONGZHEN (CN)
HU HUAIZHONG (CN)
Application Number:
PCT/CN2020/139414
Publication Date:
July 08, 2021
Filing Date:
December 25, 2020
Export Citation:
Assignee:
BEIJING KONRUNS PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/675; A61K9/20; A61K9/48
Foreign References:
| CN102093421A | 2011-06-15 | |||
| CN1197456A | 1998-10-28 | |||
| CN106290600A | 2017-01-04 | |||
| CN102408411A | 2012-04-11 | |||
| US20100093727A1 | 2010-04-15 |
Other References:
CHEN YOU-SHENG,ZHANG JIAN-HONG: "Research on How to Improve Solubility of Water-Insoluable Drugs", STRAIT PHARMACEUTICAL JOURNAL, vol. 20, no. 7, 15 July 2008 (2008-07-15), pages 25 - 27, XP055825978, ISSN: 1006-3765
YU LI, QIAN ZHAO, PEI HU , JI JIANG: "CX1003 Quantification by Ultra-Performance LC–MS/MS in Human Plasma and its Application to a Pharmacokinetic Study in Solid Tumor Patients", BIOANALYSIS, vol. 11, no. 16, 3 September 2019 (2019-09-03), pages 1483 - 1493, XP009528826, ISSN: 1757-6180, DOI: 10.4155/bio-2019-0096
YU LI, QIAN ZHAO, PEI HU , JI JIANG: "CX1003 Quantification by Ultra-Performance LC–MS/MS in Human Plasma and its Application to a Pharmacokinetic Study in Solid Tumor Patients", BIOANALYSIS, vol. 11, no. 16, 3 September 2019 (2019-09-03), pages 1483 - 1493, XP009528826, ISSN: 1757-6180, DOI: 10.4155/bio-2019-0096
Attorney, Agent or Firm:
UNI-INTEL PATENT AND TRADEMARK LAW FIRM (CN)
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