Title:
ANTI-TUMOR POLYPEPTIDES AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/181402
Kind Code:
A1
Abstract:
Polypeptides having anti-tumor activity, said artificially designed polypeptides being able to simultaneously suppress expression of PD-L1 and PD-1 in cells. Further disclosed are a key functional fragment of the anti-tumor polypeptides, and derivative forms retaining the activity thereof. The described polypeptides exhibit anti-tumor activity in mouse tumor experiments, and are capable of reducing expression of PD-L1 in tumor cells, while also reducing expression of PD-1 in vaccinated cells in a tumor microenvironment.
Inventors:
HU XIMU (CN)
Application Number:
PCT/CN2019/074726
Publication Date:
September 17, 2020
Filing Date:
March 10, 2019
Export Citation:
Assignee:
HU XIMU (CN)
International Classes:
C07K7/08; C12N15/11; A61P35/00
Domestic Patent References:
| WO2017220602A1 | 2017-12-28 |
Foreign References:
| CN108840923A | 2018-11-20 | |||
| CN107353326A | 2017-11-17 | |||
| CN109071639A | 2018-12-21 | |||
| CN107556367A | 2018-01-09 | |||
| CN103917243A | 2014-07-09 | |||
| CN107459559A | 2017-12-12 | |||
| CN109053862A | 2018-12-21 | |||
| CN106832002A | 2017-06-13 |
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