Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANTIBACTERIAL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2020/206594
Kind Code:
A1
Abstract:
Described are 1, 2, 4-substituted azetidine compounds of formula I, as well as pharmaceutical compositions and dosage forms comprising the compounds, and their use as a medicament. The compounds may find use as antibacterial agents, in particular against M. tuberculosis.

Inventors:
NEAGOIE CLEOPATRA DANIELA (CN)
PENG XUDAN (CN)
TORTORELLA MICKY DANIEL (CN)
FOSSEY JOHN S (GB)
ALDERWICK LUKE JOHN (GB)
FEULA ANTONIO (US)
YOSHIZAWA AKINA (JP)
Application Number:
PCT/CN2019/081767
Publication Date:
October 15, 2020
Filing Date:
April 08, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
UNIV BIRMINGHAM (GB)
GUANGZHOU INST BIOMED & HEALTH (CN)
International Classes:
C07D205/04; A61K31/415; A61K31/4178; A61P31/06; C07D205/00; C07D205/02
Other References:
ANTONIO FEULA , SUNDEEP S. DHILLON , RAMA BYRAVAN , MANDEEP SANGHA , RONALD EBANKS , MARIWAN A. HAMA SALIH , NEIL SPENCER , LOUISE: "Synthesis of azetidines and pyrrolidines via iodocyclisation of homoallyl amines and exploration of activity in a zebrafish embryo assay", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 11, 3 July 2013 (2013-07-03), pages 5083 - 5093, XP055741457, ISSN: 1477-0520, DOI: 10.1039/c3ob41007b
AKINA YOSHIZAWA, FEULA ANTONIO, MALE LOUISE, LEACH ANDREW G., FOSSEY JOHN S: "Rigid and concave,2,4-cis-substituted azetidine derivatives:A platform for asymmetric catalysis", SCIENTIFIC REPORTS, vol. 8, 6541, 25 April 2018 (2018-04-25), pages 1 - 16, XP055741462, ISSN: 2045-2322, DOI: 10.1038/s41598-018-24784-3
YOSHIZAWA AKINA, FEULA ANTONIO, LEACH ANDREW G., MALE LOUISE, FOSSEY JOHN S: "Palladium and Platinum 2,4-cis-amino Azetidine and Related Complexes", FRONTIERS IN CHEMISTRY, vol. 6, 21 June 2018 (2018-06-21), pages 1 - 9, XP055741467, ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00211
ANTONIO FEULA, LOUISE MALE, JOHN S. FOSSEY: "Diastereoselective Preparation of Azetidines and Pyrrolidines", ORGANIC LETTERS, vol. 12, no. 21, 29 September 2010 (2010-09-29), pages 5044 - 5047, XP055741472, ISSN: 1523-7060, DOI: 10.1021/ol102215e
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
Download PDF: