Title:
ANTIBIOTIC AGENTS
Document Type and Number:
WIPO Patent Application WO2000078772
Kind Code:
A3
Abstract:
Methods of treating a microbial infection comprising administering to a patient in need of such treatment are disclosed. In one aspect the method comprises administering to a patient in need of such treatment a therapeutically effective amount of Erythromycin B (or a pharmaceutically acceptable derivative thereof). In another aspect the method comprises a pharmaceutical composition comprising at least 50 % by weight of Erythromycin B (or a pharmaceutically acceptable derivative thereof) of the total weight of antibiotic present in the composition. Also disclosed are 2'-esters of Erythromycin B and Erythromycin B enol ether.
Inventors:
BARBER JILL (GB)
MORDI MOHAMMED NIZAM (GB)
MORDI MOHAMMED NIZAM (GB)
Application Number:
PCT/GB2000/002217
Publication Date:
March 21, 2002
Filing Date:
June 19, 2000
Export Citation:
Assignee:
UNIV MANCHESTER (GB)
BARBER JILL (GB)
MORDI MOHAMMED NIZAM (GB)
BARBER JILL (GB)
MORDI MOHAMMED NIZAM (GB)
International Classes:
A61K9/10; A61K9/20; A61K9/48; A61K9/08; A61K31/7048; A61P31/00; A61P31/04; A61P31/06; C07H17/08; (IPC1-7): A61P31/00; A61K31/7048; C07H17/08
Domestic Patent References:
| WO1998033482A1 | 1998-08-06 |
Foreign References:
| EP0553353A1 | 1993-08-04 |
Other References:
MARTIN, YVONNE C. ET AL: "Chemical modification of erythromycin antibiotics. 4. Structure-activity relations of erythromycin esters", J. MED. CHEM. (1972), 15(6), 635-8, XP001024313
OMURA, SADAFUMI ET AL: "Research and development of clarithromycin", YAKUGAKU ZASSHI (1992), 112(9), 593-614, XP002096748
JONES, PETER H. ET AL: "Chemical modifications of erythromycin antibiotics. 3. Synthesis of 4'' and 11 esters of erythromycin A and B", J. MED. CHEM. (1972), 15(6), 631-4, XP002178020
ONO, HIDEO ET AL: "Drug resistance in Staphylococcus aureus. Induction of macrolide resistance by erythromycin, oleandomycin, and their derivatives", JPN. J. MICROBIOL. (1975), 19(5), 343-7, XP001028153
BOJARSKA-DAHLIG, HALINA ET AL: "Quantitative structure-activity relationships in erythromycin group with MTD technique", POL. J. PHARMACOL. PHARM. (1981), 33(3), 359-63, XP001028146
KIBWAGE I O ET AL: "ANTIBACTERIAL ACTIVITIES OF ERYTHROMYCINS A B C AND D AND SOME OF THEIR DERIVATIVES", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 28, no. 5, 1985, pages 630 - 633, XP001028634, ISSN: 0066-4804
CANE, DAVID E. ET AL: "Macrolide biosynthesis. 3. Stereochemistry of the chain-elongation steps of erythromycin biosynthesis", J. AM. CHEM. SOC. (1986), 108(16), 4957-64, XP002178022
MORDI, MOHD N. ET AL.: "Acid-Catalyzed Degradation of Clarithromycin and Erythromycin B: A Comparative Study Using NMR Spectroscopy", J. MED. CHEM., vol. 43, no. 3, 2000, pages 467 - 474, XP001028101
BOJARSKA-DAHLIG, H.: "Correlation of physicochemical parameters and antibacterial activity of macrocyclic antibiotics", ABH. AKAD. WISS. DDR, ABT. MATH., NATURWISS., TECH. (1978), (2N, QUANT. STRUCT.-ACT. ANAL.), 343-9, XP001028142
NATL COORD GROUP INVEST SHORT-COURSE CHEMOTHER: "SHORT COURSE CHEMO THERAPY IN PULMONARY TUBERCULOSIS.", CHIN J TUBERC RESPIR DIS, (1982) 5 (2), 78-81., XP001028067
OMURA, SADAFUMI ET AL: "Research and development of clarithromycin", YAKUGAKU ZASSHI (1992), 112(9), 593-614, XP002096748
JONES, PETER H. ET AL: "Chemical modifications of erythromycin antibiotics. 3. Synthesis of 4'' and 11 esters of erythromycin A and B", J. MED. CHEM. (1972), 15(6), 631-4, XP002178020
ONO, HIDEO ET AL: "Drug resistance in Staphylococcus aureus. Induction of macrolide resistance by erythromycin, oleandomycin, and their derivatives", JPN. J. MICROBIOL. (1975), 19(5), 343-7, XP001028153
BOJARSKA-DAHLIG, HALINA ET AL: "Quantitative structure-activity relationships in erythromycin group with MTD technique", POL. J. PHARMACOL. PHARM. (1981), 33(3), 359-63, XP001028146
KIBWAGE I O ET AL: "ANTIBACTERIAL ACTIVITIES OF ERYTHROMYCINS A B C AND D AND SOME OF THEIR DERIVATIVES", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 28, no. 5, 1985, pages 630 - 633, XP001028634, ISSN: 0066-4804
CANE, DAVID E. ET AL: "Macrolide biosynthesis. 3. Stereochemistry of the chain-elongation steps of erythromycin biosynthesis", J. AM. CHEM. SOC. (1986), 108(16), 4957-64, XP002178022
MORDI, MOHD N. ET AL.: "Acid-Catalyzed Degradation of Clarithromycin and Erythromycin B: A Comparative Study Using NMR Spectroscopy", J. MED. CHEM., vol. 43, no. 3, 2000, pages 467 - 474, XP001028101
BOJARSKA-DAHLIG, H.: "Correlation of physicochemical parameters and antibacterial activity of macrocyclic antibiotics", ABH. AKAD. WISS. DDR, ABT. MATH., NATURWISS., TECH. (1978), (2N, QUANT. STRUCT.-ACT. ANAL.), 343-9, XP001028142
NATL COORD GROUP INVEST SHORT-COURSE CHEMOTHER: "SHORT COURSE CHEMO THERAPY IN PULMONARY TUBERCULOSIS.", CHIN J TUBERC RESPIR DIS, (1982) 5 (2), 78-81., XP001028067
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