Title:
ANTIBODIES BINDING LAG-3 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/166987
Kind Code:
A1
Abstract:
Provided are antibodies and antibody fragments specifically binding LAG-3, and pharmaceutical compositions containing the antibodies or the antibody fragments. A nucleic acid encoding the antibodies, a host cell comprising the nucleic acid, and a method for preparing the antibodies are provided. Further provided are therapeutic and diagnostic uses of the antibodies binding LAG-3.
Inventors:
WANG RONGJUAN (CN)
JIAO SHASHA (CN)
ZHANG CHANG (CN)
WANG SHUANG (CN)
JIAO SHASHA (CN)
ZHANG CHANG (CN)
WANG SHUANG (CN)
Application Number:
PCT/CN2022/075525
Publication Date:
August 11, 2022
Filing Date:
February 08, 2022
Export Citation:
Assignee:
MABWELL SHANGHAI BIOSCIENCE CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; C12N5/10
Domestic Patent References:
| WO2019141092A1 | 2019-07-25 |
Foreign References:
| CN112074541A | 2020-12-11 | |||
| CN111050792A | 2020-04-21 | |||
| CN108472349A | 2018-08-31 | |||
| CN110615840A | 2019-12-27 | |||
| US20180127496A1 | 2018-05-10 |
Other References:
CHEN XIUXIU;YU XIAOJIE;LIU JIANFEI;WU CHENGLIN;QIN KEWEI;ZHOU LIJUN: "Preparation of Anti-lymphocyte Activation Gene 3 (LAG-3) Fully Human Antibodies", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 36, no. 5, 18 May 2020 (2020-05-18), pages 451 - 456, XP055956448, ISSN: 1007-8738, DOI: 10.13423/j.cnki.cjcmi.009022
YU XIAOJIE, HUANG XIAO, CHEN XIUXIU, LIU JIANFEI, WU CHENGLIN, PU QIAN, WANG YUXIAO, KANG XIAOQIANG, ZHOU LIJUN: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy", MABS, vol. 11, no. 6, 18 August 2019 (2019-08-18), US , pages 1139 - 1148, XP055825981, ISSN: 1942-0862, DOI: 10.1080/19420862.2019.1629239
YU XIAOJIE, HUANG XIAO, CHEN XIUXIU, LIU JIANFEI, WU CHENGLIN, PU QIAN, WANG YUXIAO, KANG XIAOQIANG, ZHOU LIJUN: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy", MABS, vol. 11, no. 6, 18 August 2019 (2019-08-18), US , pages 1139 - 1148, XP055825981, ISSN: 1942-0862, DOI: 10.1080/19420862.2019.1629239
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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