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Title:
ANTIBODIES HAVING SPECIFICITY FOR THE ORF2I PROTEIN OF HEPATITIS E VIRUS AND USES THEREOF FOR DIAGNOSTIC PURPOSES
Document Type and Number:
WIPO Patent Application WO/2020/011755
Kind Code:
A8
Abstract:
Hepatitis E virus (HEV) is annually responsible for 20 million infections with 3.4 million symptomatic cases and 70,000 deaths mainly occurring in less developed regions of the world. HEV is a non-enveloped virus containing a linear, single-stranded, positive-sense RNA genome that contains three open reading frames (ORFs), namely, ORF1, ORF2 and ORF3. ORF2 encodes the ORF2 viral capsid protein, which is involved in particle assembly, binding to host cells and eliciting neutralizing antibodies. Recently, 3 different forms of the ORF2 capsid protein were identified: infectious/intracellular ORF2 (ORF2i), glycosylated ORF2 (ORF2g), and cleaved ORF2 (ORF2c). The ORF2i protein, for which the precise sequence has been identified, is the form that is associated with infectious particles and thus antibodies having specificity for the ORF2i protein would be suitable for the diagnosis of HEV. The present fulfills this need by providing an antibody which binds to the ORF2i protein of hepatitis E virus and wherein said antibody does not bind to the ORF2g protein nor to the ORF2c of hepatitis E virus, and wherein the epitope of said antibody comprises at least one amino acid residue from amino acid residues 542 to 555 of SEQ ID NO: 1.

Inventors:
COCQUEREL-DEPROY, Laurence (1 rue du Professeur Calmette, Lille cedex, FR)
MONTPELLIER, Claire (1 rue du Professeur Calmette, Lille cedex, FR)
DUBUISSON, Jean (CNRS UMR8204 1 rue du Professeur Calmette, Lille cedex, FR)
Application Number:
EP2019/068341
Publication Date:
April 22, 2021
Filing Date:
July 09, 2019
Export Citation:
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Assignee:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (Paris, Paris, FR)
INSTITUT PASTEUR DE LILLE (Lille, Lille, FR)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (Paris, Paris, FR)
UNIVERSITÉ DE LILLE (Lille, FR)
International Classes:
C07K16/10; G01N33/576
Attorney, Agent or Firm:
INSERM TRANSFERT (Paris, FR)
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