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Title:
ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING KLEBSIELLA PNEUMONIAE O1 ANTIGEN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/025173
Kind Code:
A1
Abstract:
An antibody or antigen-binding fragment capable of specifically recognizing klebsiella pneumoniae O1, and a preparation method therefor and the use thereof.

Inventors:
NIU YUQIANG (CN)
YAN LI (CN)
LI ZHONG (CN)
Application Number:
PCT/CN2022/114384
Publication Date:
March 02, 2023
Filing Date:
August 24, 2022
Export Citation:
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Assignee:
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K16/12; A61K39/395; A61K39/40; G01N33/569
Foreign References:
CN109843917A2019-06-04
CN107371365A2017-11-21
US20180298084A12018-10-18
US20180312576A12018-11-01
Other References:
HELD, T. K. ET AL.: "Binding to and Opsonophagocytic Activity of O-Antigen-Specific Monoclonal Antibodies against Encapsulated and Nonencapsulated Klebsiella pneumoniae Serotype O1 Strains", INFECTION AND IMMUNITY, vol. 68, no. 5, 31 May 2000 (2000-05-31), XP055258752, DOI: 10.1128/IAI.68.5.2402-2409.2000
KOBAYASHI SCOTT D., ADELINE R PORTER, BRETT FREEDMAN, RUCHI PANDEY, LIANG CHEN, BARRY N KREISWIRTH, FRANK R DELEO: "Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils", MBIO, vol. 9, no. 2, 13 March 2018 (2018-03-13), XP093038819, DOI: 10.1128/mBio.00297-18
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