Title:
ANTIBODY COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2020/067541
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an antibody composition which more selectively exhibits an effector function to damage target cells expressing two different types of antigen, and which is capable of retaining sufficiently high affinity for the individual target antigens. This invention is an antibody composition against a first antigen and a second antigen, which are different from each other, the composition being formed from a first IgG halfmer and a second IgG halfmer.
Inventors:
NIWA RINPEI (JP)
USAMI KATSUAKI (JP)
USAMI KATSUAKI (JP)
Application Number:
PCT/JP2019/038421
Publication Date:
April 02, 2020
Filing Date:
September 27, 2019
Export Citation:
Assignee:
KYOWA KIRIN CO LTD (JP)
International Classes:
A61K39/395; C12N15/13; A61P43/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
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Other References:
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CARTRON GDACHEUX LSALLES G ET AL., BLOOD, vol. 99, 2002, pages 754 - 8
WENG WKLEVY R., J CLIN ONCOL, vol. 21, 2003, pages 3940 - 7
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AALBERSE RCSCHUURMAN J, IMMUNOLOGY, vol. 105, 2002, pages 9 - 10
LABRIJN AF, NAT BIOTECHNOL, vol. 27, 2009, pages 767 - 71
SONDERMANN P, NATURE, vol. 406, 2000, pages 267 - 73
RADAEV S, J BIOL CHEM, vol. 276, 2001, pages 16469 - 77
FERRARA C, PROC NATL ACAD SCI, vol. 108, 2011, pages 12660 - 74
MIZUSHIMA T, GENES CELLS, vol. 16, 2011, pages 1071 - 80
STROHL WR, CURR OPIN BIOTECHNOL, vol. 20, 2009, pages 685 - 91
NIWA R, J PHARM SCI, 2015, pages 930 - 41
BECK A, MABS, vol. 4, 2012, pages 419 - 25
GOEDE V, N ENGL J MED, vol. 370, 2014, pages 1101 - 10
BYRNE H, TRENDS BIOTECHNOL, vol. 31, 2013, pages 621 - 32
MAZOR Y, MABS, vol. 7, 2015, pages 377 - 89
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
BRINKMANN U ET AL., MABS, vol. 9, 2017, pages 182 - 212
FERNANDES CFC ET AL., FRONTIERS IN IMMUNOLOGY, vol. 8, 2017, pages 653
TOMIZUKA K. ET AL., PROC NATL ACAD SCI USA., vol. 97, 2000, pages 722 - 7
WINTER G. ET AL., ANNU REV IMMUNOL., vol. 12, 1994, pages 433 - 55
ROSEN A. ET AL., NATURE, vol. 267, 1977, pages 52 - 54
CHEM. TODAY, 2003, pages 65
CURR OPIN CHEM BIOL, vol. 6, 2000, pages 645
"Biochemical Experimentation Methods", vol. 23, 1989, JAPAN SCIENTIFIC SOCIETIES PRESS, article "Method for Studying Glycoprotein Sugar Chain"
J. LIQ. CHROMATOGR., vol. 6, 1983, pages 1577
"Current Protocols in Molecular Biology; Antibodies, A Laboratory manual", 1988, COLD SPRING HARBOR LABORATORY, article "Molecular Cloning"
"Monoclonal Antibodies: principles and practice", 1993, ACAD. PRESS
AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 63, 1996, pages 627S
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
NATURE, vol. 329, 1987, pages 840
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
METHODS IN ENZYMOL, vol. 154, 1987, pages 3
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY
DNA CLONING: A PRACTICAL APPROACH, vol. I, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENE, vol. 38, 1985, pages 275
SCIENCE, vol. 222, 1983, pages 778
JOURNAL OF MOLECULAR BIOLOGY
J. MOL. BIOL., vol. 1, 1983, pages 166
J. MOL. BIOL., vol. 16, 1966, pages 118
SANGER ET AL., PROC. NATL. ACAD. SCI. U. S. A., vol. 74, 1977, pages 5463
BIO/TECHNOLOGY, vol. 9, 1991, pages 830
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
ANAL. BIOCHEM., vol. 171, 1988, pages 73
PROC. NATL. ACAD. SCI. U. S. A., vol. 84, 1987, pages 7413
"Biomanual Series 4-Methods of Gene Transfer, Expression and Analysis", 1994, YODOSHA, article "Manipulating Mouse Embryo"
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
METHODS ENZYMOL., vol. 194, 1990, pages 182
PROC. NATL. ACAD. SCI. U. S. A., vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
NATURE, vol. 227, 1970, pages 680
AGRIC. BIOL. CHEM., vol. 55, no. 1, 1991, pages 283 - 284
"Methods of Studies on Glycoprotein Sugar Chains", vol. 23, 1989, JAPAN SCIENTIFIC SOCIETIES PRESS, article "Biochemical Experimentation Methods"
J. BIOCHEM., vol. 95, 1984, pages 197
"Enzyme Immunoassay", 1987, IGAKU-SHOIN LTD.
"Enzyme Antibody Technique", 1985, GAKUSAI KIKAKU
J. IMMUNOL., vol. 187, 2011, pages 3238 - 3246
J. IMMUNOL., vol. 149, 1992, pages 1779 - 1787
See also references of EP 3858994A4
CARTER P., NAT REV CANCER, vol. 1, 2001, pages 118 - 29
CARTRON GDACHEUX LSALLES G ET AL., BLOOD, vol. 99, 2002, pages 754 - 8
WENG WKLEVY R., J CLIN ONCOL, vol. 21, 2003, pages 3940 - 7
"Monoclonal Antibodies: Principles and Applications", 1995, WILEY-LISS, INC., pages: 45
AALBERSE RCSCHUURMAN J, IMMUNOLOGY, vol. 105, 2002, pages 9 - 10
LABRIJN AF, NAT BIOTECHNOL, vol. 27, 2009, pages 767 - 71
SONDERMANN P, NATURE, vol. 406, 2000, pages 267 - 73
RADAEV S, J BIOL CHEM, vol. 276, 2001, pages 16469 - 77
FERRARA C, PROC NATL ACAD SCI, vol. 108, 2011, pages 12660 - 74
MIZUSHIMA T, GENES CELLS, vol. 16, 2011, pages 1071 - 80
STROHL WR, CURR OPIN BIOTECHNOL, vol. 20, 2009, pages 685 - 91
NIWA R, J PHARM SCI, 2015, pages 930 - 41
BECK A, MABS, vol. 4, 2012, pages 419 - 25
GOEDE V, N ENGL J MED, vol. 370, 2014, pages 1101 - 10
BYRNE H, TRENDS BIOTECHNOL, vol. 31, 2013, pages 621 - 32
MAZOR Y, MABS, vol. 7, 2015, pages 377 - 89
ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
BRINKMANN U ET AL., MABS, vol. 9, 2017, pages 182 - 212
FERNANDES CFC ET AL., FRONTIERS IN IMMUNOLOGY, vol. 8, 2017, pages 653
TOMIZUKA K. ET AL., PROC NATL ACAD SCI USA., vol. 97, 2000, pages 722 - 7
WINTER G. ET AL., ANNU REV IMMUNOL., vol. 12, 1994, pages 433 - 55
ROSEN A. ET AL., NATURE, vol. 267, 1977, pages 52 - 54
CHEM. TODAY, 2003, pages 65
CURR OPIN CHEM BIOL, vol. 6, 2000, pages 645
"Biochemical Experimentation Methods", vol. 23, 1989, JAPAN SCIENTIFIC SOCIETIES PRESS, article "Method for Studying Glycoprotein Sugar Chain"
J. LIQ. CHROMATOGR., vol. 6, 1983, pages 1577
"Current Protocols in Molecular Biology; Antibodies, A Laboratory manual", 1988, COLD SPRING HARBOR LABORATORY, article "Molecular Cloning"
"Monoclonal Antibodies: principles and practice", 1993, ACAD. PRESS
AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 63, 1996, pages 627S
CYTOTECHNOLOGY, vol. 3, 1990, pages 133
NATURE, vol. 329, 1987, pages 840
J. BIOCHEMISTRY, vol. 101, 1987, pages 1307
METHODS IN ENZYMOL, vol. 154, 1987, pages 3
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 9494
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY
DNA CLONING: A PRACTICAL APPROACH, vol. I, 1985, pages 49
MOL. CELL. BIOL., vol. 3, 1983, pages 280
GENE, vol. 38, 1985, pages 275
SCIENCE, vol. 222, 1983, pages 778
JOURNAL OF MOLECULAR BIOLOGY
J. MOL. BIOL., vol. 1, 1983, pages 166
J. MOL. BIOL., vol. 16, 1966, pages 118
SANGER ET AL., PROC. NATL. ACAD. SCI. U. S. A., vol. 74, 1977, pages 5463
BIO/TECHNOLOGY, vol. 9, 1991, pages 830
J. MOL. BIOL., vol. 112, 1977, pages 535
PROTEIN ENGINEERING, vol. 7, 1994, pages 1501
PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413
ANAL. BIOCHEM., vol. 171, 1988, pages 73
PROC. NATL. ACAD. SCI. U. S. A., vol. 84, 1987, pages 7413
"Biomanual Series 4-Methods of Gene Transfer, Expression and Analysis", 1994, YODOSHA, article "Manipulating Mouse Embryo"
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
METHODS ENZYMOL., vol. 194, 1990, pages 182
PROC. NATL. ACAD. SCI. U. S. A., vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
NATURE, vol. 227, 1970, pages 680
AGRIC. BIOL. CHEM., vol. 55, no. 1, 1991, pages 283 - 284
"Methods of Studies on Glycoprotein Sugar Chains", vol. 23, 1989, JAPAN SCIENTIFIC SOCIETIES PRESS, article "Biochemical Experimentation Methods"
J. BIOCHEM., vol. 95, 1984, pages 197
"Enzyme Immunoassay", 1987, IGAKU-SHOIN LTD.
"Enzyme Antibody Technique", 1985, GAKUSAI KIKAKU
J. IMMUNOL., vol. 187, 2011, pages 3238 - 3246
J. IMMUNOL., vol. 149, 1992, pages 1779 - 1787
See also references of EP 3858994A4
Attorney, Agent or Firm:
Eikoh Patent Firm, P.C. (JP)
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