Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANTIBODY FOR NEUTRALIZING SUBSTANCE HAVING COAGULATION FACTOR VIII (F.VIII) FUNCTION-SUBSTITUTING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2021/235537
Kind Code:
A1
Abstract:
Production was attempted for an antibody that neutralizes the activity of a bispecific antibody having F.VIII function-substituting activity, for use in a method for measuring the reactivity of F.VIII in the presence of a bispecific antibody having F.VIII function-substituting activity. As a result, it was found that use of the produced antibody made it possible to accurately evaluate F.VIII activity in blood plasma of a hemophilia A patient, in an APTT-based one-stage clotting assay with respect to a wide range of bispecific antibodies having F.VIII function-substituting activity. Furthermore, it was found that it was also possible to accurately evaluate F.VIII inhibitor titer in blood plasma of a hemophilia A patient having an F.VIII inhibitor, in an APTT-based Bethesda assay.

Inventors:
SOEDA TETSUHIRO (JP)
HADANO JINKI (JP)
Application Number:
PCT/JP2021/019299
Publication Date:
November 25, 2021
Filing Date:
May 21, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/40; C12N15/13; C07K16/42; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08; G01N33/53; G01N33/86
Domestic Patent References:
WO2016047656A12016-03-31
WO2019065795A12019-04-04
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Download PDF: