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Title:
ANTICONVULSANT DERIVATIVES USEFUL FOR TREATING AND PREVENTING THE DEVELOPMENT OF TYPE II DIABETES MELLITUS AND SYNDROME X
Document Type and Number:
WIPO Patent Application WO2002003984
Kind Code:
A3
Abstract:
Anticonvulsant derivatives of formula (I) useful for preventing the development of Type II diabetes mellitus and Syndrome X are disclosed. Wherein X is CH 2 or oxygen; R<1> is hydrogen or alkyl; and R<2>, R<3>, R<4> and R<5> are independently hydrogen or lower alkyl and when X is CH2, R<4> and R<5> may be alkene groups joined to form a benzene ring and, when X is oxygen, R<2> and R<3> and/or R<4> and R<5> together may be a methylenedioxy group of the following formula (II) : wherein R<6> and R<7> are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.

Inventors:
PLATA-SALAMAN CARLOS
CROOKE JEFFREY
Application Number:
PCT/US2001/021404
Publication Date:
March 06, 2003
Filing Date:
July 06, 2001
Export Citation:
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Assignee:
ORTHO MCNEIL PHARM INC (US)
International Classes:
C07H9/04; A61K31/255; A61K31/35; A61K31/357; A61K31/36; A61K31/7042; A61K31/7048; A61P3/10; A61P5/50; (IPC1-7): A61K31/255; A61K31/35; A61K31/7048; A61P3/10; A61P5/50
Domestic Patent References:
WO2000076493A12000-12-21
WO2000061139A12000-10-19
WO1999044581A21999-09-10
WO1998000130A21998-01-08
Foreign References:
Other References:
DEMAREST, KEITH (1) ET AL: "Topiramate improves glucose tolerance and may improve insulin sensitivity in animal models of type 2 diabetes mellitus.", DIABETES, (JUNE, 2001) VOL. 50, NO. SUPPLEMENT 2, PP. A302. PRINT. MEETING INFO.: 61ST SCIENTIFIC SESSIONS OF THE AMERICAN DIABETES ASSOCIATION PHILADELPHIA, PENNSYLVANIA, USA JUNE 22-26, 2001, XP008011145
OSBORNE, MELVILLE C. (1) ET AL: "Topiramate improves glycemic control and triglycerides in animal models.", DIABETES, (JUNE, 2001) VOL. 50, NO. SUPPLEMENT 2, PP. A302-A303. PRINT. MEETING INFO.: 61ST SCIENTIFIC SESSIONS OF THE AMERICAN DIABETES ASSOCIATION PHILADELPHIA, PENNSYLVANIA, USA JUNE 22-26, 2001, XP008011144
YORK D A ET AL: "EFFECTS OF TOPIRAMATE ON HIGH FAT DIET-INDUCED OBESITY", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 14, no. 4, April 2000 (2000-04-01), pages A431, XP000915192, ISSN: 0892-6638
"The Merck Manual", 1999, MERCK RESEARCH, WHITEHOUSE STATION, N.J., XP002224345
EDWARDS K R ET AL: "Efficacy and safety of topiramate in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study ADIS TITLE: Topiramate: therapeutic use.;Neurogenic pain; In patients with diabetic neuropathy", NEUROLOGY NEUROLOGY 54 (SUPPL. 3): 81, 11 APR 2000. (APR 11, 2000), Bennington, Vermont, USA, XP008011155
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