Title:
ANTIFIBROTIC AGENT AND BIOMARKER FOR FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2019/202767
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a molecule having a significant effect on the development of fibrosis and a substance capable of inhibiting fibrosis. This biomarker for fibrosis comprises RNA binding motif protein 7 (RBM7) and is useful as a biomarker for diagnosis of fibrosis. This fibrosis detection method comprising the step of detecting RBM7 in a biological sample from a subject preferably using an anti-RBM7 antibody is useful for diagnosis of fibrosis. This antifibrotic agent containing a substance which inhibits the expression of RBM7, preferably at least one nucleic acid drug selected from the group consisting of siRNAs, shRNAs, dsRNAs, miRNAs, and antisense nucleic acids against RBM7, is useful for treatment of fibrosis.
Inventors:
SATOH TAKASHI (JP)
AKIRA SHIZUO (JP)
AKIRA SHIZUO (JP)
Application Number:
PCT/JP2018/043644
Publication Date:
October 24, 2019
Filing Date:
November 27, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K45/00; A61K31/7088; A61K31/7105; A61K31/713; A61K48/00; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P43/00; C12Q1/02; C12Q1/6851; C12Q1/686; G01N33/15; G01N33/50; G01N33/53; G01N33/68; C12N15/113
Domestic Patent References:
| WO2008085035A1 | 2008-07-17 | |||
| WO2008085024A1 | 2008-07-17 |
Foreign References:
| JP2002523045A | 2002-07-30 | |||
| JP2018504138A | 2018-02-15 |
Other References:
KIYOHARU FUKUSHIMA, SO SATO, HIROSHI KIDA, ATSUSHI KUMANOGO, SHIZUO AKIRA: "MS66. Control of organ fibrosis through non-coding RNA degradation by RBM7", ANNALS OF THE JAPANESE RESPIRATORY SOCIETY, vol. 7, 10 March 2018 (2018-03-10), pages 146, XP009524442, ISSN: 2186-5876
KIYOHARU FUKUSHIMA; SO SATO; HIROSHI KIDA; ATSUSHI KUMANOSATO; SHIZUO AKIRA: "270 Identification of new molecular targets involved in pulmonary fibrosis progression", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE; 115TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 107, 14 April 2018 (2018-04-14), pages 217, XP009524443, ISSN: 0021-5384, DOI: 10.2169/naika.107.149a
MICHAEL C LEVIN: "Multiple Sclerosis", 31 March 2014 (2014-03-31), pages 1 - 4, XP009524450, Retrieved from the Internet
J. CLIN. INVEST., vol. 115, 2005, pages 209 - 218
EXP. BIOL. MED. (MAYWOOD, vol. 233, 2008, pages 109 - 122
J. HEPATOL., vol. 56, 2012, pages 965 - 972
IMMUNITY, vol. 34, 2011, pages 85 - 95
CELL, vol. 157, 2014, pages 832 - 844
NATURE, vol. 496, 2013, pages 445 - 455
NAT. IMMUNOL., vol. 11, 2010, pages 936 - 944
ANNU. REV. PATHOL., vol. 8, 2013, pages 241 - 276
NAT. REV. IMMUNOL., vol. 14, 2014, pages 181 - 194
NATURE, vol. 541, 2017, pages 96 - 101
"Uniprot", Database accession no. Q9Y580
"GenBank", Database accession no. AF156098
TATIANA A. TATSUSOVATHOMAS L. MADDEN, FEMS MICROBIOL. LETT., vol. 174, 1999, pages 247 - 250
See also references of EP 3782647A4
KIYOHARU FUKUSHIMA; SO SATO; HIROSHI KIDA; ATSUSHI KUMANOSATO; SHIZUO AKIRA: "270 Identification of new molecular targets involved in pulmonary fibrosis progression", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE; 115TH ANNUAL MEETING OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 107, 14 April 2018 (2018-04-14), pages 217, XP009524443, ISSN: 0021-5384, DOI: 10.2169/naika.107.149a
MICHAEL C LEVIN: "Multiple Sclerosis", 31 March 2014 (2014-03-31), pages 1 - 4, XP009524450, Retrieved from the Internet
J. CLIN. INVEST., vol. 115, 2005, pages 209 - 218
EXP. BIOL. MED. (MAYWOOD, vol. 233, 2008, pages 109 - 122
J. HEPATOL., vol. 56, 2012, pages 965 - 972
IMMUNITY, vol. 34, 2011, pages 85 - 95
CELL, vol. 157, 2014, pages 832 - 844
NATURE, vol. 496, 2013, pages 445 - 455
NAT. IMMUNOL., vol. 11, 2010, pages 936 - 944
ANNU. REV. PATHOL., vol. 8, 2013, pages 241 - 276
NAT. REV. IMMUNOL., vol. 14, 2014, pages 181 - 194
NATURE, vol. 541, 2017, pages 96 - 101
"Uniprot", Database accession no. Q9Y580
"GenBank", Database accession no. AF156098
TATIANA A. TATSUSOVATHOMAS L. MADDEN, FEMS MICROBIOL. LETT., vol. 174, 1999, pages 247 - 250
See also references of EP 3782647A4
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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