Title:
ANTIFUNGAL COMPOUND, SYNTHESIS METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/227436
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of medicine synthesis, relates to an antifungal compound, and in particular relates to an antifungal compound, a synthesis method and the use thereof, wherein the antifungal compound is an amino acid carbon ester or a pharmaceutically acceptable salt thereof, and the amino acid carbon ester has the following structural formula (I). R1 is one of a C5-C17 alkane group or a C5-C17 alkylene group; and R2 is an amino acid side chain group. The present invention also provides a method for synthesizing the antifungal compound and the use of the antifungal compound in the antifungal field.
Inventors:
PEI ZEJUN (CN)
SUN XIN (CN)
SUN XIN (CN)
Application Number:
PCT/CN2020/130777
Publication Date:
November 18, 2021
Filing Date:
November 23, 2020
Export Citation:
Assignee:
WUXI NO 2 PEOPLES HOSPITAL (CN)
International Classes:
A61K31/223; C07C229/08; A61P31/10; C07C227/18; C07C227/40; C07C229/22; C07C277/08; C07C279/14
Domestic Patent References:
| WO2014093252A1 | 2014-06-19 | |||
| WO2015000076A1 | 2015-01-08 | |||
| WO2013173759A2 | 2013-11-21 |
Foreign References:
| JP2015061826A | 2015-04-02 | |||
| CN111087317A | 2020-05-01 | |||
| US3821403A | 1974-06-28 |
Other References:
YAMADA TAISUKE, LUKAC PAUL JOSEPH, YU TAO, WEISS RICHARD G.: "Reversible, Room-Temperature, Chiral Ionic Liquids. Amidinium Carbamates Derived from Amidines and Amino-Acid Esters with Carbon Dioxide", CHEMISTRY OF MATERIALS, vol. 19, no. 19, 1 September 2007 (2007-09-01), US , pages 4761 - 4768, XP055867211, ISSN: 0897-4756, DOI: 10.1021/cm0713531
INOUE Y., FUKUSHIMA T., HAYAKAWA T., OGURA R., KAMINISHI H., MIYAZAKI K., OKAHATA Y.: "Antifungal activity of DNA-lipid complexes and DNA-lipid films againstCandida species", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 76A, no. 1, 1 January 2006 (2006-01-01), US , pages 126 - 132, XP055867330, ISSN: 1549-3296, DOI: 10.1002/jbm.a.30394
I. V. KAPATINOV ET. AL.: "Synthesis, self assembly, bacterial and fungal toxicity of a series of L-phenylalaninederived surface active ionic liquids.", GREEN CHEMISTRY, vol. 21, no. 7, 12 March 2019 (2019-03-12), pages 1777 - 1794, XP002798952, DOI: 10.1039/c9gc00030e
TIAN, WEI: "Amino Acid Advanced Alkyl Ester Fungicide", AGROCHEMICALS, no. 2, 31 December 1987 (1987-12-31), pages 23 - 25, XP055867338
SHIDA, TOSHIRO; HOMMA, YASUO; MISATO, TOMOMASA: "Effect of N-Phenacetylamino Acids, N-Naphtylamino Acids, N-Alkyl Amino Acids and Amino Acid Esters on Rice Blast", NIPPON NOGEIKAGAKU KAISHI, vol. 48, no. 9, 31 December 1974 (1974-12-31), JP , pages 515 - 519, XP009531821, ISSN: 0002-1407, DOI: 10.1271/nogeikagaku1924.48.515
DATABASE REGISTRY 6 October 1985 (1985-10-06), ANONYMOUS: "L-Leucine, 9-octadecenyl ester, (Z)- (9CI) (CA INDEX NAME)", XP055867418, retrieved from STN Database accession no. 98474-39-6
INOUE Y., FUKUSHIMA T., HAYAKAWA T., OGURA R., KAMINISHI H., MIYAZAKI K., OKAHATA Y.: "Antifungal activity of DNA-lipid complexes and DNA-lipid films againstCandida species", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 76A, no. 1, 1 January 2006 (2006-01-01), US , pages 126 - 132, XP055867330, ISSN: 1549-3296, DOI: 10.1002/jbm.a.30394
I. V. KAPATINOV ET. AL.: "Synthesis, self assembly, bacterial and fungal toxicity of a series of L-phenylalaninederived surface active ionic liquids.", GREEN CHEMISTRY, vol. 21, no. 7, 12 March 2019 (2019-03-12), pages 1777 - 1794, XP002798952, DOI: 10.1039/c9gc00030e
TIAN, WEI: "Amino Acid Advanced Alkyl Ester Fungicide", AGROCHEMICALS, no. 2, 31 December 1987 (1987-12-31), pages 23 - 25, XP055867338
SHIDA, TOSHIRO; HOMMA, YASUO; MISATO, TOMOMASA: "Effect of N-Phenacetylamino Acids, N-Naphtylamino Acids, N-Alkyl Amino Acids and Amino Acid Esters on Rice Blast", NIPPON NOGEIKAGAKU KAISHI, vol. 48, no. 9, 31 December 1974 (1974-12-31), JP , pages 515 - 519, XP009531821, ISSN: 0002-1407, DOI: 10.1271/nogeikagaku1924.48.515
DATABASE REGISTRY 6 October 1985 (1985-10-06), ANONYMOUS: "L-Leucine, 9-octadecenyl ester, (Z)- (9CI) (CA INDEX NAME)", XP055867418, retrieved from STN Database accession no. 98474-39-6
Attorney, Agent or Firm:
WUXI HUICHENGYONGXIN PATENT FIRM( GENERAL PARTNERSHIP) (CN)
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