ANTIMALARIAL AGENTS

WIPO Patent Application WO/2021/026884

A1

Methods for treating malaria comprises administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

JP2002543199	INDUSTRIAL APPLICABILITY 1-aminotriazolo [4,3-a] quinazoline-5-one and / or -5-thione that inhibit phosphodiesterase IV
WO/2019/167981	4-METHYLDIHYDROPYRIMIDINONE COMPOUND AND MEDICINAL USE THEREOF

MCCAULEY A JOHN (US)
COWMAN F ALAN (AU)
DE LERA RUIZ MANUEL (US)
FAVUZZA PAOLA (AU)
GUO ZHUYAN (US)
HU BIN (CN)
LEI ZHIYU (CN)
OLSEN DAVID (US)
SLEEBS EDMUND BRAD (AU)
THOMPSON K JENNIFER (AU)
TRIGLIA TONY (AU)
ZHAN DONGMEI (CN)
ZHANG CAILING (CN)
ZHAO LIANYUN (CN)

PCT/CN2019/100781

February 18, 2021

August 15, 2019

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MERCK SHARP & DOHME (US)
MCCAULEY A JOHN (US)
COWMAN F ALAN (AU)
DE LERA RUIZ MANUEL (US)
FAVUZZA PAOLA (AU)
GUO ZHUYAN (US)
HU BIN (CN)
LEI ZHIYU (CN)
OLSEN DAVID (US)
SLEEBS EDMUND BRAD (AU)
THOMPSON K JENNIFER (AU)
TRIGLIA TONY (AU)
ZHAN DONGMEI (CN)
ZHANG CAILING (CN)
ZHAO LIANYUN (CN)
WALTER & ELIZA HALL INST MEDICAL RES (AU)
MSD R&D CHINA CO LTD (CN)

C07D239/22; A61K31/513; A61P33/06; C07D405/04; C07D405/14

WO2017142825A2	2017-08-24
WO2008103351A2	2008-08-28
WO2017089453A1	2017-06-01
WO2011044181A1	2011-04-14
WO2017144517A1	2017-08-31

WU, FENG & ZHANG (CN)

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