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Title:
ANTIMICROBIAL PEPTIDES ISOLATED FROM MAST CELLS
Document Type and Number:
WIPO Patent Application WO2002014345
Kind Code:
A3
Abstract:
Antimicrobial peptides (endobiotic peptides) isolated from mast cells are described, along with compositions containing the same and methods of use thereof. Such peptides obtained from fish mast cells are referred to as "piscidins" herein.

Inventors:
NOGA EDWARD J (US)
SILPHADUANG UMAPORN (US)
Application Number:
PCT/US2001/041696
Publication Date:
May 30, 2002
Filing Date:
August 13, 2001
Export Citation:
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Assignee:
UNIV NORTH CAROLINA STATE (US)
NOGA EDWARD J (US)
SILPHADUANG UMAPORN (US)
International Classes:
C07K14/46; A61K38/00; (IPC1-7): A61K38/00
Domestic Patent References:
WO1989000199A11989-01-12
WO1994021672A11994-09-29
Foreign References:
Other References:
SILPHADUANG ET AL.: "Peptide antibiotics in mast cell of fish", NATURE, vol. 414, no. 6861, November 2001 (2001-11-01), pages 268 - 269, XP002906958
BOMAN H.G.: "Peptide antibiotics and their role in innate immunity", ANNUAL REVIEW OF IMMUNOLOGY, vol. 13, 1995, pages 61 - 92, XP002906959
YU K. ET AL.: "Relationship between the tertiary structures of mastoparan B and its analogs and their lytic activities studied by NMR spectroscopy", JOURNAL OF PEPTIDE RESEARCH, vol. 54, 2000, pages 51 - 62, XP002906960
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