ANTITUMOR AGENT, METHOD OF PRODUCING ANTITUMOR AGENT, MEDICINAL COMPOSITION CONTAINING ANTITUMOR AGENT AND MICROORGANISM PRODUCING ANTITUMOR AGENT

WIPO Patent Application WO/2005/112951

A1

It is intended to provide an antitumor agent, which has established a strengthened function selectivity of acting exclusively on caner cells, lessened side effects, mastery of drug tolerance and so on, and has an activity of inducing cell death in human lung small cell carcinoma Ms-1 cells and human lung small cell carcinoma Ms-1/Bcl-2 cells and Ms-1/Bcl-XL cells with the overexpression of an apoptosis-inhibitory protein Bcl-2 or Bcl-XL, and so on. Namely, an antitumor agent characterized by being a compound represented by the following general formula or its derivative. [Chemical formula 12] wherein R represents a hydrogen atom or an alkyl group.

TAKAHASHI YOSHIKAZU (JP)
SAWA RYUICHI (JP)
IMOTO MASAYA (JP)
FUTAMURA YUSHI (JP)

PCT/JP2005/009185

December 01, 2005

May 19, 2005

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MICROBIAL CHEM RES FOUND (JP)
TAKAHASHI YOSHIKAZU (JP)
SAWA RYUICHI (JP)
IMOTO MASAYA (JP)
FUTAMURA YUSHI (JP)

A61K31/7052; A61K35/74; A61P35/00; C07H17/02; C12N1/20; C12P17/16; C12R1/465; (IPC1-7): A61K31/7052; A61P35/00; C07H17/02; C12N1/20; C12P17/16

THAWAI C. ET AL: "Micromonosporin A, a novel 24-membered polyene lactant macrolide from Micromonospora sp. isolated from peat swamp forest.", CHEMISTRY & BIODIVERSITY., vol. 1, no. 4, 2004, pages 640 - 645, XP002990822

Hirota, Koichi (NAGARE & ASSOCIATES 8th Floor, Miyata Bldg., 1-38-2, Yoyog, Shibuya-ku Tokyo, JP)

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